DSpace Repository

A review on the interactions between gut microbiota and innate immunity of fish

Show simple item record

dc.creator Gómez, Geovanny D.
dc.creator Balcázar, José Luis
dc.date 2008-04-16T11:06:59Z
dc.date 2008-04-16T11:06:59Z
dc.date 2008
dc.date.accessioned 2017-01-31T01:02:27Z
dc.date.available 2017-01-31T01:02:27Z
dc.identifier FEMS Immunology & Medical Microbiology 52: 145-154 (2008)
dc.identifier http://hdl.handle.net/10261/3618
dc.identifier 10.1111/j.1574-695X.2007.00343.x
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3618
dc.description Review
dc.description Although fish immunology has progressed in the last few years, the contribution of the normal endogenous microbiota to the overall health status has been so far underestimated. In this context, the establishment of a normal or protective microbiota constitutes a key component to maintain good health, through competitive exclusion mechanisms, and has implications for the development and maturation of the immune system. The normal microbiota influences the innate immune system, which is of vital importance for the disease resistance of fish and is divided into physical barriers, humoral and cellular components. Innate humoral parameters include antimicrobial peptides, lysozyme, complement components, transferrin, pentraxins, lectins, antiproteases and natural antibodies, whereas nonspecific cytotoxic cells and phagocytes (monocytes/macrophages and neutrophils) constitute innate cellular immune effectors. Cytokines are an integral component of the adaptive and innate immune response, particularly IL-1b, interferon, tumor necrosis factor-a, transforming growth factor-b and several chemokines regulate innate immunity. This review covers the innate immune mechanisms of protection against pathogens, in relation with the installation and composition of the normal endogenous microbiota in fish and its role on health. Knowledge of such interaction may offer novel and useful means designing adequate therapeutic strategies for disease prevention and treatment.
dc.description Peer reviewed
dc.format 126791 bytes
dc.format application/pdf
dc.language eng
dc.publisher Blackwell Publishing
dc.rights closedAccess
dc.title A review on the interactions between gut microbiota and innate immunity of fish
dc.type Artículo


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account