| dc.creator |
Stein, Jens V. |
|
| dc.creator |
López Fraga, Marta |
|
| dc.creator |
Elustondo, Fernando A. |
|
| dc.creator |
Carvalho-Pinto, Carla E. |
|
| dc.creator |
Rodríguez Aguirre, Dolores |
|
| dc.creator |
Gómez Caro, Ruth |
|
| dc.creator |
Jong, Joan de |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.creator |
Medema, Jan Paul |
|
| dc.creator |
Hahne, Michael |
|
| dc.date |
2008-04-16T09:36:37Z |
|
| dc.date |
2008-04-16T09:36:37Z |
|
| dc.date |
2002-06 |
|
| dc.date.accessioned |
2017-01-31T01:02:26Z |
|
| dc.date.available |
2017-01-31T01:02:26Z |
|
| dc.identifier |
The Journal of Clinical Investigation, vol. 109(12), pp. 1587-1598, (2002) |
|
| dc.identifier |
0021-9738 |
|
| dc.identifier |
http://hdl.handle.net/10261/3613 |
|
| dc.identifier |
10.1172/JCI15034 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3613 |
|
| dc.description |
The final version of this paper is available at: http://dx.doi.org/10.1172/JCI15034 |
|
| dc.description |
The TNF-like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA. BLyS has been shown to play an important role in B cell homeostasis and autoimmunity, but the biological role of APRIL remains less well defined. Analysis of T cells revealed an activation-dependent increase in APRIL mRNA expression. We therefore generated mice expressing APRIL as a transgene in T cells. These mice appeared normal and showed no signs of B cell hyperplasia.
Transgenic T cells revealed a greatly enhanced survival in vitro as well as enhanced survival of staphylococcal enterotoxin B-reactive CD4+ T cells in vivo, which both directly correlate with elevated Bcl-2 levels. Analysis of humoral responses to T cell-dependent antigens in the transgenic mice indicated that APRIL affects only IgM but not IgG responses. In contrast, T cell-independent type 2 (TI-2) humoral response was enhanced in APRIL transgenic mice. As TACI was previously reported to be indispensable for TI-2 antibody formation, these results suggest a role for APRIL/TACI interactions in the generation of this response. Taken together, our data indicate that APRIL is involved in the induction and/or maintenance of T and B cell responses. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
990129 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
American Society for Clinical Investigation |
|
| dc.rights |
openAccess |
|
| dc.title |
APRIL modulates B and T cell immunity |
|
| dc.type |
Artículo |
|