| dc.creator |
Varona, Rosa |
|
| dc.creator |
Villares, Ricardo |
|
| dc.creator |
Carramolino, Laura |
|
| dc.creator |
Goya, Íñigo |
|
| dc.date |
2008-04-16T08:58:39Z |
|
| dc.date |
2008-04-16T08:58:39Z |
|
| dc.date |
2001-03 |
|
| dc.date.accessioned |
2017-01-31T01:02:25Z |
|
| dc.date.available |
2017-01-31T01:02:25Z |
|
| dc.identifier |
The Journal of Clinical Investigation,vol. 107, 2001, March, pp. R37-45 |
|
| dc.identifier |
0021-9738 |
|
| dc.identifier |
http://hdl.handle.net/10261/3607 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3607 |
|
| dc.description |
El copyright pertenece a The American Society for Clinical Investigation |
|
| dc.description |
CCR6 expression in dendritic, T, and B cells suggests that this b-chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory
and immunological responses. Here we demonstrate that CCR6–/– mice have underdeveloped Peyer’s patches, in which the myeloid CD11b+ CD11c+ dendritic-cell subset is not present in the subepithelial
dome. CCR6–/– mice also have increased numbers in T-cell subpopulations within the intestinal mucosa. In 2,4-dinitrofluorobenzene–induced contact hypersensitivity (CHS) studies, CCR6–/– mice developed more severe and more persistent inflammation than wild-type (WT) animals. Conversely, in a delayedtype
hypersensitivity (DTH) model induced with allogeneic splenocytes, CCR6–/– mice developed no inflammatory response. The altered responses seen in the CHS and DTH assays suggest the existence
of a defect in the activation and/or migration of the CD4+ T-cell subsets that downregulate or elicit the inflammation response, respectively. These findings underscore the role of CCR6 in cutaneous and
intestinal immunity and the utility of CCR6–/– mice as a model to study pathologies in these tissues. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
1804153 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
American Society for Clinical Investigation |
|
| dc.rights |
openAccess |
|
| dc.title |
CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses |
|
| dc.type |
Artículo |
|