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CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

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dc.creator Varona, Rosa
dc.creator Villares, Ricardo
dc.creator Carramolino, Laura
dc.creator Goya, Íñigo
dc.date 2008-04-16T08:58:39Z
dc.date 2008-04-16T08:58:39Z
dc.date 2001-03
dc.date.accessioned 2017-01-31T01:02:25Z
dc.date.available 2017-01-31T01:02:25Z
dc.identifier The Journal of Clinical Investigation,vol. 107, 2001, March, pp. R37-45
dc.identifier 0021-9738
dc.identifier http://hdl.handle.net/10261/3607
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3607
dc.description El copyright pertenece a The American Society for Clinical Investigation
dc.description CCR6 expression in dendritic, T, and B cells suggests that this b-chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses. Here we demonstrate that CCR6–/– mice have underdeveloped Peyer’s patches, in which the myeloid CD11b+ CD11c+ dendritic-cell subset is not present in the subepithelial dome. CCR6–/– mice also have increased numbers in T-cell subpopulations within the intestinal mucosa. In 2,4-dinitrofluorobenzene–induced contact hypersensitivity (CHS) studies, CCR6–/– mice developed more severe and more persistent inflammation than wild-type (WT) animals. Conversely, in a delayedtype hypersensitivity (DTH) model induced with allogeneic splenocytes, CCR6–/– mice developed no inflammatory response. The altered responses seen in the CHS and DTH assays suggest the existence of a defect in the activation and/or migration of the CD4+ T-cell subsets that downregulate or elicit the inflammation response, respectively. These findings underscore the role of CCR6 in cutaneous and intestinal immunity and the utility of CCR6–/– mice as a model to study pathologies in these tissues.
dc.description Peer reviewed
dc.format 1804153 bytes
dc.format application/pdf
dc.language eng
dc.publisher American Society for Clinical Investigation
dc.rights openAccess
dc.title CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses
dc.type Artículo


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