أعرض تسجيلة المادة بشكل مبسط
| dc.creator |
Campo, Rosa Del |
|
| dc.creator |
Tenorio, Carmen |
|
| dc.creator |
Jiménez Díaz, Rufino |
|
| dc.creator |
Rubio, Carmen |
|
| dc.creator |
Gómez-Lus, Rafael |
|
| dc.creator |
Baquero, Fernando |
|
| dc.creator |
Torres, Carmen |
|
| dc.date |
2008-04-11T07:19:18Z |
|
| dc.date |
2008-04-11T07:19:18Z |
|
| dc.date |
2001-03 |
|
| dc.date.accessioned |
2017-01-31T01:01:59Z |
|
| dc.date.available |
2017-01-31T01:01:59Z |
|
| dc.identifier |
Antimicrobial Agents and Chemotherapy 45(3): 905–912 (2001) |
|
| dc.identifier |
1098-6596 |
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| dc.identifier |
http://hdl.handle.net/10261/3533 |
|
| dc.identifier |
10.1128/AAC.45.3.905-912.2001 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3533 |
|
| dc.description |
Bacteriocin production was determined for 218 Enterococcus isolates (Enterococcus faecalis [93] and E. faecium
[125]) obtained from different origins (human clinical samples [87], human fecal samples [78], sewage [28],
and chicken samples [25]) and showing different vancomycin susceptibility patterns (vancomycin resistant, all
of them vanA positive [56], and vancomycin susceptible [162]). All enterococcal isolates were randomly selected
except for the vancomycin-resistant ones. A total of 33 isolates of eight different bacterial genera were
used as indicators for bacteriocin production. Forty-seven percent of the analyzed enterococcal isolates were
bacteriocin producers (80.6% of E. faecalis and 21.6% of E. faecium isolates). The percentage of bacteriocin
producers was higher among human clinical isolates (63.2%, 81.8% of vancomycin-resistant isolates and 60.5%
of vancomycin-susceptible ones) than among isolates from the other origins (28 to 39.3%). Only one out of the
15 vancomycin-resistant isolates from human fecal samples was a bacteriocin producer, while 44.4% of fecal
vancomycin-susceptible isolates were. The bacteriocin produced by the vanA-containing E. faecium strain RC714,
named bacteriocin RC714, was further characterized. This bacteriocin activity was cotransferred together with
the vanA genetic determinant to E. faecalis strain JH2-2. Bacteriocin RC714 was purified to homogeneity and
its primary structure was determined by amino acid sequencing, showing an identity of 88% and a similarity of
92% with the previously described bacteriocin 31 from E. faecalis YI717. The presence of five different amino acids
in bacteriocin RC714 suggest that this could be a new bacteriocin. The results obtained suggest that the epidemiology
of vancomycin resistance may be influenced by different factors, including bacteriocin production. |
|
| dc.description |
R. D. C. was supported by a grant from the Diputación General de
Aragón of Spain (project P49/97) and from the Sociedad Española de
Quimioterapia. This work has been supported in part by a grant from
the Fondo de Investigaciones Sanitarias (00/0545) of Spain. |
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| dc.description |
Peer reviewed |
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| dc.format |
320677 bytes |
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| dc.format |
application/pdf |
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| dc.language |
eng |
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| dc.publisher |
American Society for Microbiology |
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| dc.rights |
closedAccess |
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| dc.title |
Bacteriocin Production in Vancomycin-Resistant and Vancomycin-Susceptible Enterococcus Isolates of Different Origins |
|
| dc.type |
Artículo |
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