| dc.creator |
Rodríguez Frade, José M. |
|
| dc.creator |
Vila-Coro, Antonio J. |
|
| dc.creator |
Nieto, Marta |
|
| dc.creator |
Sánchez Madrid, Francisco |
|
| dc.creator |
Proudfoot, Amanda |
|
| dc.creator |
Wells, Timothy N.C. |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.creator |
Mellado, Mario |
|
| dc.date |
2008-04-08T12:36:32Z |
|
| dc.date |
2008-04-08T12:36:32Z |
|
| dc.date |
1999-02 |
|
| dc.date.accessioned |
2017-01-31T01:01:38Z |
|
| dc.date.available |
2017-01-31T01:01:38Z |
|
| dc.identifier |
The Journal of Cell Biology, 144 (4): 755-765 (1999) |
|
| dc.identifier |
0021-9525 |
|
| dc.identifier |
http://hdl.handle.net/10261/3476 |
|
| dc.identifier |
10.1083/jcb.144.4.755 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3476 |
|
| dc.description |
11 páginas, 8 figuras. |
|
| dc.description |
Chemokines are a family of proinflammatory
cytokines that attract and activate specific types of leukocytes.
Chemokines mediate their effects via interaction with seven transmembrane G proteinÐcoupled receptors
(GPCR). Using CCR5-transfected HEK-293
cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)-RANTES, trigger immediate responses such as Ca2+
influx, receptor dimerization, tyrosine phosphorylation,and Gai as well as JAK/STAT association to the receptor.
In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by the association of focal adhesion kinase (FAK) to the
chemokine receptor complex, impaired cell polarization required for migration, or chemotaxis. The results
are discussed in the context of the dissociation of the late signals, provoked by the chemokines required for
cell migration, from early signals. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
744445 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.relation |
http://dx.doi.org/10.1083/jcb.144.4.755 |
|
| dc.rights |
openAccess |
|
| dc.subject |
Chemokines |
|
| dc.subject |
Receptor dimerization |
|
| dc.subject |
Inflammation |
|
| dc.subject |
HIV-1 |
|
| dc.title |
Similarities and differences in RANTES and (AOP)-RANTES-triggered signals : implications for chemotaxis |
|
| dc.type |
Artículo |
|