| dc.creator |
López, Escarlata |
|
| dc.creator |
Guerrero, Rosario |
|
| dc.creator |
Núñez, Maria Isabel |
|
| dc.creator |
Moral, Rosario del |
|
| dc.creator |
Villalobos, Mercedes |
|
| dc.creator |
Martínez-Galán, Joaquina |
|
| dc.creator |
Valenzuela, María Teresa |
|
| dc.creator |
Muñoz-Gámez, José A. |
|
| dc.creator |
Oliver, Francisco Javier |
|
| dc.creator |
Martín-Oliva, David |
|
| dc.creator |
Ruiz de Almodóvar, José Mariano |
|
| dc.date |
2008-04-08T10:09:27Z |
|
| dc.date |
2008-04-08T10:09:27Z |
|
| dc.date |
2005-07-01 |
|
| dc.date.accessioned |
2017-01-31T01:01:37Z |
|
| dc.date.available |
2017-01-31T01:01:37Z |
|
| dc.identifier |
Breast Cancer Research 2005, 7:R690-R698 |
|
| dc.identifier |
1465-542X |
|
| dc.identifier |
http://hdl.handle.net/10261/3468 |
|
| dc.identifier |
10.1186/bcr1277 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3468 |
|
| dc.description |
This article is online at: http://breast-cancer-research.com/content/7/5/R690 |
|
| dc.description |
[Introduction] Radiotherapy outcomes might be further improved
by a greater understanding of the individual variations in normal
tissue reactions that determine tolerance. Most published
studies on radiation toxicity have been performed
retrospectively. Our prospective study was launched in 1996 to
measure the in vitro radiosensitivity of peripheral blood
lymphocytes before treatment with radical radiotherapy in
patients with breast cancer, and to assess the early and the late
radiation skin side effects in the same group of patients. We
prospectively recruited consecutive breast cancer patients
receiving radiation therapy after breast surgery. To evaluate
whether early and late side effects of radiotherapy can be
predicted by the assay, a study was conducted of the
association between the results of in vitro radiosensitivity tests
and acute and late adverse radiation effects. |
|
| dc.description |
[Methods] Intrinsic molecular radiosensitivity was measured by
using an initial radiation-induced DNA damage assay on
lymphocytes obtained from breast cancer patients before
radiotherapy. Acute reactions were assessed in 108 of these
patients on the last treatment day. Late morbidity was assessed
after 7 years of follow-up in some of these patients. The
Radiation Therapy Oncology Group (RTOG) morbidity score
system was used for both assessments. |
|
| dc.description |
[Results] Radiosensitivity values obtained using the in vitro test
showed no relation with the acute or late adverse skin reactions
observed. There was no evidence of a relation between acute
and late normal tissue reactions assessed in the same patients.
A positive relation was found between the treatment volume and
both early and late side effects. |
|
| dc.description |
[Conclusion] After radiation treatment, a number of cells
containing major changes can have a long survival and
disappear very slowly, becoming a chronic focus of
immunological system stimulation. This stimulation can produce,
in a stochastic manner, late radiation-related adverse effects of
varying severity. Further research is warranted to identify the
major determinants of normal tissue radiation response to make
it possible to individualize treatments and improve the outcome
of radiotherapy in cancer patients. |
|
| dc.description |
This work was supported by grants from the Ministerio de Ciencia y Tecnología
CICYT (SAF 2001-3533) and Ministerio de Educación y Ciencia
CICYT (SAF 2004-00889). DMO and JAMG were supported by
fellowships (BEFI 01/9331, BEFI 02/9029) from the Fondo de Investigaciones
Sanitarias (ISCIII). |
|
| dc.description |
Peer reviewed |
|
| dc.format |
326536 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.rights |
openAccess |
|
| dc.title |
Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes |
|
| dc.type |
Artículo |
|