| dc.creator |
Cerezo, Ana |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.creator |
Lanzarot, Diego |
|
| dc.creator |
Fischer, Siegmund |
|
| dc.creator |
Franke, Thomas F. |
|
| dc.creator |
Rebollo, Angelita |
|
| dc.date |
2008-04-08T09:50:19Z |
|
| dc.date |
2008-04-08T09:50:19Z |
|
| dc.date |
1998-11 |
|
| dc.date.accessioned |
2017-01-31T01:01:37Z |
|
| dc.date.available |
2017-01-31T01:01:37Z |
|
| dc.identifier |
Molecular Biology of the Cell, Vol. 8, pp. 3107–3118, November 1998 |
|
| dc.identifier |
1059-1524 |
|
| dc.identifier |
http://hdl.handle.net/10261/3467 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3467 |
|
| dc.description |
El copyright pertenece a The American Society for Cell Biology.
The final versión of the paper is available at
http://www.pubmedcentral.nih.gov |
|
| dc.description |
We have shown previously that interleukin-4 (IL-4) protects TS1ab cells from apoptosis, but very little is known about the mechanism by which IL-4 exerts this effect. We found that Akt activity, which is dependent on phosphatidylinositol 3 kinase, is reduced in IL-4-deprived TS1ab cells. Overexpression of wild-type Akt or a constitutively active Akt mutant protects
cells from IL-4 deprivation-induced apoptosis. Readdition of IL-4 before the commitment point is able to restore Akt activity. We also show expression and c-Jun N-terminal kinase 2 activation after IL-4 deprivation. Overexpression of the constitutively activated Akt mutant
in IL-4-deprived cells correlates with inhibition of c-Jun N-terminal kinase 2 activity. Finally, TS1ab survival is independent of Bcl-2, Bcl-x, or Bax. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
360048 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
American Society for Cell Biology |
|
| dc.rights |
openAccess |
|
| dc.title |
Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation |
|
| dc.type |
Artículo |
|