| dc.creator |
Ruíz Vela, Antonio |
|
| dc.creator |
Serrano Gómez, Fernando |
|
| dc.creator |
González de la Peña, Manuel Angel |
|
| dc.creator |
Abad, José Luis |
|
| dc.creator |
Bernad, Antonio |
|
| dc.creator |
Maki, Masatoshi |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.date |
2008-04-02T11:47:16Z |
|
| dc.date |
2008-04-02T11:47:16Z |
|
| dc.date |
2001-08 |
|
| dc.date.accessioned |
2017-01-31T01:01:26Z |
|
| dc.date.available |
2017-01-31T01:01:26Z |
|
| dc.identifier |
The Journal of Experimental Medicine, volume 194, number 3, august 6, 2001, pp. 247–254 |
|
| dc.identifier |
0022-1007 |
|
| dc.identifier |
http://hdl.handle.net/10261/3420 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3420 |
|
| dc.description |
Copyright © by The Rockefeller University Press |
|
| dc.description |
Long-term cultured pre-B cells are able to differentiate into immunoglobulin (Ig)M-positive B cells (IgM cells) when transplanted into severe combined immunodeficient (SCID) mice.
Based on previous studies, here we report the development of a reconstitution assay in nonobese diabetic/SCID (NOD/SCID) mice using pre-B cells, which allows us to study the role of calpains (calcium-activated endopeptidases) during B cell development as well as in B cell clonal deletion. Using this model, we show that calpastatin (the natural inhibitor of calpains)
inhibits B cell receptor–induced apoptosis in IgM cells derived from transplanted mice. We thus hypothesize an important function for calpain in sculpting the B cell repertoire. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
455975 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.rights |
openAccess |
|
| dc.subject |
pre-B cells |
|
| dc.subject |
Calpastatin |
|
| dc.subject |
Calpain |
|
| dc.subject |
BCR |
|
| dc.subject |
Transplant |
|
| dc.title |
Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis |
|
| dc.type |
Artículo |
|