أعرض تسجيلة المادة بشكل مبسط

dc.creator Stich, Michael
dc.creator Briones, Carlos
dc.creator Manrubia Cuevas, Susanna
dc.date 2008-04-01T12:36:05Z
dc.date 2008-04-01T12:36:05Z
dc.date 2007-07-09
dc.date.accessioned 2017-01-31T01:01:24Z
dc.date.available 2017-01-31T01:01:24Z
dc.identifier BMC Evol Biol. 2007; 7: 110
dc.identifier 1471-2148
dc.identifier http://hdl.handle.net/10261/3406
dc.identifier 10.1186/1471-2148-7-110
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3406
dc.description This article is available from: http://www.biomedcentral.com/1471-2148/7/110
dc.description [Background] RNA molecules, through their dual appearance as sequence and structure, represent a suitable model to study evolutionary properties of quasispecies. The essential ingredient in this model is the differentiation between genotype (molecular sequences which are affected by mutation) and phenotype (molecular structure, affected by selection). This framework allows a quantitative analysis of organizational properties of quasispecies as they adapt to different environments, such as their robustness, the effect of the degeneration of the sequence space, or the adaptation under different mutation rates and the error threshold associated.
dc.description [Results]We describe and analyze the structural properties of molecular quasispecies adapting to different environments both during the transient time before adaptation takes place and in the asymptotic state, once optimization has occurred. We observe a minimum in the adaptation time at values of the mutation rate relatively far from the phenotypic error threshold. Through the definition of a consensus structure, it is shown that the quasispecies retains relevant structural information in a distributed fashion even above the error threshold. This structural robustness depends on the precise shape of the secondary structure used as target of selection. Experimental results available for natural RNA populations are in qualitative agreement with our observations.
dc.description [Conclusion] Adaptation time of molecular quasispecies to a given environment is optimized at values of the mutation rate well below the phenotypic error threshold. The optimal value results from a trade-off between diversity generation and fixation of advantageous mutants. The critical value of the mutation rate is a function not only of the sequence length, but also of the specific properties of the environment, in this case the selection pressure and the shape of the secondary structure used as target phenotype. Certain functional motifs of RNA secondary structure that withstand high mutation rates (as the ubiquitous hairpin motif) might appear early in evolution and be actually frozen evolutionary accidents.
dc.description This research was supported by project FIS2004-06414 of Spanish MEC.
dc.description Peer reviewed
dc.format 473663 bytes
dc.format application/pdf
dc.language eng
dc.publisher BioMed Central
dc.relation Publisher’s version
dc.rights openAccess
dc.title Collective properties of evolving molecular quasispecies
dc.type Artículo


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أعرض تسجيلة المادة بشكل مبسط