| dc.creator |
Lois, Sergi |
|
| dc.creator |
Blanco, Noemí |
|
| dc.creator |
Martínez-Balbás, Marian |
|
| dc.creator |
Cruz, Xavier de la |
|
| dc.date |
2008-04-01T09:35:42Z |
|
| dc.date |
2008-04-01T09:35:42Z |
|
| dc.date |
2007-07-25 |
|
| dc.date.accessioned |
2017-01-31T01:01:24Z |
|
| dc.date.available |
2017-01-31T01:01:24Z |
|
| dc.identifier |
BMC Genomics. 2007; 8: 252 |
|
| dc.identifier |
1471-2164 |
|
| dc.identifier |
http://hdl.handle.net/10261/3400 |
|
| dc.identifier |
10.1186/1471-2164-8-252 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3400 |
|
| dc.description |
This article is available from: http://www.biomedcentral.com/1471-2164/8/252 |
|
| dc.description |
[Background] Epigenetic regulators (histone acetyltransferases, methyltransferases, chromatinremodelling
enzymes, etc) play a fundamental role in the control of gene expression by modifying
the local state of chromatin. However, due to their recent discovery, little is yet known about their
own regulation. This paper addresses this point, focusing on alternative splicing regulation, a
mechanism already known to play an important role in other protein families, e.g. transcription
factors, membrane receptors, etc. |
|
| dc.description |
[Results] To this end, we compiled the data available on the presence/absence of alternative splicing
for a set of 160 different epigenetic regulators, taking advantage of the relatively large amount of
unexplored data on alternative splicing available in public databases. We found that 49 % (70 % in
human) of these genes express more than one transcript. We then studied their alternative splicing
patterns, focusing on those changes affecting the enzyme's domain composition. In general, we
found that these sequence changes correspond to different mechanisms, either repressing the
enzyme's function (e.g. by creating dominant-negative inhibitors of the functional isoform) or
creating isoforms with new functions. |
|
| dc.description |
[Conclusion] We conclude that alternative splicing of epigenetic regulators can be an important
tool for the function modulation of these enzymes. Considering that the latter control the
transcriptional state of large sets of genes, we propose that epigenetic regulation of gene
expression is itself strongly regulated by alternative splicing. |
|
| dc.description |
The authors are grateful to the SwissProt team for their support. XdC
acknowledges funding from the Spanish government (grants BIO2003-
09327, BIO2006-15557). MM-B and NB acknowledge funding from the
Spanish government (grants SAF2002-00741, SAF2005-01285, Gen2003-
20642, CSD2006-00049, and BFU2006-01493/BMC). NB acknowledges
financial support from the Parc Científic de Barcelona. SL acknowledges
financial support from the Consejo Superior de Investigaciones Científicas. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
158208 bytes |
|
| dc.format |
730847 bytes |
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| dc.format |
application/vnd.ms-excel |
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| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.relation |
http://dx.doi.org/10.1186/1471-2164-8-252 |
|
| dc.rights |
openAccess |
|
| dc.title |
The functional modulation of epigenetic regulators by alternative splicing |
|
| dc.type |
Artículo |
|