| dc.contributor |
Ministerio de Economía y Competitividad (España) |
|
| dc.contributor |
Fundación Ramón Areces |
|
| dc.creator |
Villa-Cuesta, Eugenia |
|
| dc.creator |
González-Pérez, Esther |
|
| dc.creator |
Modolell, Juan |
|
| dc.date |
2008-03-27T11:42:24Z |
|
| dc.date |
2008-03-27T11:42:24Z |
|
| dc.date |
2007-09-19 |
|
| dc.date.accessioned |
2017-01-31T01:01:09Z |
|
| dc.date.available |
2017-01-31T01:01:09Z |
|
| dc.identifier |
BMC Developmental Biology 2007, 7:106 |
|
| dc.identifier |
1471-213X |
|
| dc.identifier |
http://hdl.handle.net/10261/3335 |
|
| dc.identifier |
10.1186/1471-213X-7-106 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3335 |
|
| dc.description |
This article is available from: http://www.biomedcentral.com/1471-213X/7/106 |
|
| dc.description |
[Background] The organization of the different tissues of an animal requires mechanisms that
regulate cell-cell adhesion to promote and maintain the physical separation of adjacent cell
populations. In the Drosophila imaginal wing disc the iroquois homeobox genes are expressed in the
notum anlage and contribute to the specification of notum identity. These genes are not expressed
in the adjacent wing hinge territory. These territories are separated by an approximately straight
boundary that in the mature disc is associated with an epithelial fold. The mechanism by which
these two cell populations are kept separate is unclear. |
|
| dc.description |
[Results] Here we show that the Iro-C genes participate in keeping the notum and wing cell
populations separate. Indeed, within the notum anlage, cells not expressing Iro-C tend to join
together and sort out from their Iro-C expressing neighbours. We also show that apposition of
Iro-C expressing and non-expressing cells induces invagination and apico-basal shortening of the
Iro-C- cells. This effect probably underlies formation of the fold that separates the notum and wing
hinge territories. In addition, cells overexpressing a member of the Iro-C contact one another and
become organized in a network of thin strings that surrounds and isolates large groups of nonoverexpressing
cells. The strings appear to exert a pulling force along their longitudinal axis. |
|
| dc.description |
[Conclusion] Apposition of cells expressing and non-expressing the Iro-C, as it occurs in the
notum-wing hinge border of the Drosophila wing disc, influences cell behaviour. It leads to cell
sorting, and cellular invagination and apical-basal shortening. These effects probably account for
keeping the prospective notum and wing hinge cell populations separate and underlie epithelial fold
formation. Cells that overexpress a member of the Iro-C and that confront non-expressing cells
establish contacts between themselves and become organized in a network of thin strings. This is
a complex and unique phenotype that might be important for the generation of a straight notumwing
hinge border. |
|
| dc.description |
Work was supported by grants from Dirección General de
Investigación Científica y Técnica (BMC2002-411, BFU2005-02888) and an
institutional grant from Fundación Ramón Areces to the Centro de Biología
Molecular Severo Ochoa. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
219909 bytes |
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| dc.format |
391742 bytes |
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| dc.format |
496767 bytes |
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| dc.format |
image/jpeg |
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| dc.format |
image/jpeg |
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| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.rights |
openAccess |
|
| dc.title |
Apposition of iroquois expressing and non-expressing cells leads to cell sorting and fold formation in the Drosophila imaginal wing disc |
|
| dc.type |
Artículo |
|