| dc.creator |
Vieira, Filipe G. |
|
| dc.creator |
Rozas, Julio |
|
| dc.creator |
Sánchez-Gracia, Alejandro |
|
| dc.date |
2008-03-27T08:46:48Z |
|
| dc.date |
2008-03-27T08:46:48Z |
|
| dc.date |
2007-11-08 |
|
| dc.date.accessioned |
2017-01-31T01:00:58Z |
|
| dc.date.available |
2017-01-31T01:00:58Z |
|
| dc.identifier |
Genome Biology 2007, 8:R235 |
|
| dc.identifier |
1465-6906 |
|
| dc.identifier |
http://hdl.handle.net/10261/3326 |
|
| dc.identifier |
10.1186/gb-2007-8-11-r235 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3326 |
|
| dc.description |
The electronic version of this article is the complete one and can be
found online at http://genomebiology.com/2007/8/11/R235 |
|
| dc.description |
[Background] Chemoreception is a widespread mechanism that is involved in critical biologic
processes, including individual and social behavior. The insect peripheral olfactory system
comprises three major multigene families: the olfactory receptor (Or), the gustatory receptor (Gr),
and the odorant-binding protein (OBP) families. Members of the latter family establish the first
contact with the odorants, and thus constitute the first step in the chemosensory transduction
pathway. |
|
| dc.description |
[Results] Comparative analysis of the OBP family in 12 Drosophila genomes allowed the
identification of 595 genes that encode putative functional and nonfunctional members in extant
species, with 43 gene gains and 28 gene losses (15 deletions and 13 pseudogenization events). The
evolution of this family shows tandem gene duplication events, progressive divergence in DNA and
amino acid sequence, and prevalence of pseudogenization events in external branches of the
phylogenetic tree. We observed that the OBP arrangement in clusters is maintained across the
Drosophila species and that purifying selection governs the evolution of the family; nevertheless,
OBP genes differ in their functional constraints levels. Finally, we detect that the OBP repertoire
evolves more rapidly in the specialist lineages of the Drosophila melanogaster group (D. sechellia and
D. erecta) than in their closest generalists. |
|
| dc.description |
[Conclusion] Overall, the evolution of the OBP multigene family is consistent with the birth-anddeath
model. We also found that members of this family exhibit different functional constraints,
which is indicative of some functional divergence, and that they might be involved in some of the
specialization processes that occurred through the diversification of the Drosophila genus. |
|
| dc.description |
This work was funded by grant BFU2004-02253 from
the Dirección General de Investigación Científica y Técnica (Spain), and by
grant 2005SGR00166 from Comissió Interdepartamental de Recerca i
Innovació Tecnològica de Catalunya (Spain). |
|
| dc.description |
Peer reviewed |
|
| dc.format |
23040 bytes |
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1500290 bytes |
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| dc.format |
application/vnd.ms-excel |
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| dc.format |
application/pdf |
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| dc.format |
application/vnd.ms-powerpoint |
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application/postscript |
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| dc.format |
application/vnd.ms-powerpoint |
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| dc.format |
application/vnd.ms-excel |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.rights |
openAccess |
|
| dc.subject |
Evolution |
|
| dc.subject |
Genome studies |
|
| dc.subject |
Model organisms |
|
| dc.title |
Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution |
|
| dc.type |
Artículo |
|