| dc.creator |
Sánchez-Pulido, Luis |
|
| dc.creator |
Andrade, Miguel A. |
|
| dc.date |
2008-03-27T08:23:42Z |
|
| dc.date |
2008-03-27T08:23:42Z |
|
| dc.date |
2007-11-08 |
|
| dc.date.accessioned |
2017-01-31T01:00:57Z |
|
| dc.date.available |
2017-01-31T01:00:57Z |
|
| dc.identifier |
BMC Biochemistry 2007, 8:23 |
|
| dc.identifier |
1471-2091 |
|
| dc.identifier |
http://hdl.handle.net/10261/3325 |
|
| dc.identifier |
10.1186/1471-2091-8-23 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3325 |
|
| dc.description |
This article is available from: http://www.biomedcentral.com/1471-2091/8/23 |
|
| dc.description |
[Background] Genetic variants in the FTO (fat mass and obesity associated) gene have been
associated with an increased risk of obesity. However, the function of its protein product has not
been experimentally studied and previously reported sequence similarity analyses suggested the
absence of homologs in existing protein databases. Here, we present the first detailed
computational analysis of the sequence and predicted structure of the protein encoded by FTO. |
|
| dc.description |
[Results] We performed a sequence similarity search using the human FTO protein as query and
then generated a profile using the multiple sequence alignment of the homologous sequences.
Profile-to-sequence and profile-to-profile based comparisons identified remote homologs of the
non-heme dioxygenase family. |
|
| dc.description |
[Conclusion] Our analysis suggests that human FTO is a member of the non-heme dioxygenase
(Fe(II)- and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation
patterns support this hypothesis and indicate that both 2-oxoglutarate and iron should be
important for FTO function. This computational prediction of the function of FTO should suggest
further steps for its experimental characterization and help to formulate hypothesis about the
mechanisms by which it relates to obesity in humans. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
1335783 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.rights |
openAccess |
|
| dc.title |
The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily |
|
| dc.type |
Artículo |
|