| dc.creator |
Gallach, Miguel |
|
| dc.creator |
Arnau, Vicente |
|
| dc.creator |
Marín, Ignacio |
|
| dc.date |
2008-03-27T08:10:38Z |
|
| dc.date |
2008-03-27T08:10:38Z |
|
| dc.date |
2007-11-09 |
|
| dc.date.accessioned |
2017-01-31T01:00:57Z |
|
| dc.date.available |
2017-01-31T01:00:57Z |
|
| dc.identifier |
BMC Genomics 2007, 8:408 |
|
| dc.identifier |
1471-2164 |
|
| dc.identifier |
http://hdl.handle.net/10261/3324 |
|
| dc.identifier |
10.1186/1471-2164-8-408 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3324 |
|
| dc.description |
This article is available from: http://www.biomedcentral.com/1471-2164/8/408 |
|
| dc.description |
[Background] Sequencing of the genomes of several Drosophila allows for the first precise analyses
of how global sequence patterns change among multiple, closely related animal species. A basic
question is whether there are characteristic features that differentiate chromosomes within a
species or between different species. |
|
| dc.description |
[Results] We explored the euchromatin of the chromosomes of seven Drosophila species to
establish their global patterns of DNA sequence diversity. Between species, differences in the types
and amounts of simple sequence repeats were found. Within each species, the autosomes have
almost identical oligonucleotide profiles. However, X chromosomes and autosomes have, in all
species, a qualitatively different composition. The X chromosomes are less complex than the
autosomes, containing both a higher amount of simple DNA sequences and, in several cases,
chromosome-specific repetitive sequences. Moreover, we show that the right arm of the X
chromosome of Drosophila pseudoobscura, which evolved from an autosome 10 – 18 millions of
years ago, has a composition which is identical to that of the original, left arm of the X
chromosome. |
|
| dc.description |
[Conclusion] The consistent differences among species, differences among X chromosomes and
autosomes and the convergent evolution of X and neo-X chromosomes demonstrate that strong
forces are acting on drosophilid genomes to generate peculiar chromosomal landscapes. We
discuss the relationships of the patterns observed with differential recombination and mutation
rates and with the process of dosage compensation. |
|
| dc.description |
This work was supported by Grant SAF2006-08977 (Ministerio de Educación
y Ciencia, Spain). |
|
| dc.description |
Peer reviewed |
|
| dc.format |
1319412 bytes |
|
| dc.format |
68608 bytes |
|
| dc.format |
application/pdf |
|
| dc.format |
application/msword |
|
| dc.language |
eng |
|
| dc.publisher |
BioMed Central |
|
| dc.relation |
Publisher’s version |
|
| dc.rights |
openAccess |
|
| dc.title |
Global patterns of sequence evolution in Drosophila |
|
| dc.type |
Artículo |
|