| dc.creator |
Esplugues, Enric |
|
| dc.creator |
Sancho, David |
|
| dc.creator |
Vega-Ramos, Javier |
|
| dc.creator |
Martínez-Alonso, Carlos |
|
| dc.creator |
Syrbe, Uta |
|
| dc.creator |
Hamann, Alf |
|
| dc.creator |
Engel, Pablo |
|
| dc.creator |
Sánchez Madrid, Francisco |
|
| dc.creator |
Lauzurica, Pilar |
|
| dc.date |
2008-03-25T07:56:32Z |
|
| dc.date |
2008-03-25T07:56:32Z |
|
| dc.date |
2003-05 |
|
| dc.date.accessioned |
2017-01-31T01:00:53Z |
|
| dc.date.available |
2017-01-31T01:00:53Z |
|
| dc.identifier |
The Journal of Experimental Medicine, Volume 197, Number 9, May 5, 2003, pp. 1093–1106 |
|
| dc.identifier |
0022-1007 |
|
| dc.identifier |
http://hdl.handle.net/10261/3282 |
|
| dc.identifier |
10.1084/jem.20021337 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/3282 |
|
| dc.description |
Copyright © by The Rockefeller University Press |
|
| dc.description |
We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69 /
mice to tumors. CD69 / mice challenged with MHC class I tumors (RMA-S and RM-1)
showed greatly reduced tumor growth and prolonged survival compared with wild-type
(WT) mice. The enhanced anti–tumor response was NK cell and T lymphocyte–mediated,
and was due, at least in part, to an increase in local lymphocytes. Resistance of CD69 / mice to MHC class I tumor growth was also associated with increased production of the chemokine MCP-1, diminished TGF- production, and decreased lymphocyte apoptosis.
Moreover, the in vivo blockade of TGF-
in WT mice resulted in enhanced anti–tumor response. In addition, CD69 engagement induced NK and T cell production of TGF- , directly linking CD69 signaling to TGF- regulation. Furthermore, anti-CD69 antibody treatment in WT mice induced a specific down-regulation in CD69 expression that resulted in augmented anti–tumor response. These data unmask a novel role for CD69 as a negative regulator of anti–tumor responses and show the possibility of a novel approach for the therapy of tumors. |
|
| dc.description |
Peer reviewed |
|
| dc.format |
263366 bytes |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
Rockefeller University Press |
|
| dc.rights |
openAccess |
|
| dc.subject |
Cytokines |
|
| dc.subject |
Homeostasis |
|
| dc.subject |
Apoptosis |
|
| dc.title |
Enhanced Antitumor Immunity in Mice Deficient in CD69 |
|
| dc.type |
Artículo |
|