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High-Q dynamic force microscopy in liquid and its application to living cells

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dc.creator Tamayo de Miguel, Francisco Javier
dc.creator Humphris, A. D. L.
dc.creator Owen, R. J.
dc.creator Miles, M. J.
dc.date 2008-01-31T18:02:55Z
dc.date 2008-01-31T18:02:55Z
dc.date 2001-07
dc.date.accessioned 2017-01-31T00:59:54Z
dc.date.available 2017-01-31T00:59:54Z
dc.identifier Biophys J. 2001 July; 81(1): 526–537.
dc.identifier 0006-3495
dc.identifier http://hdl.handle.net/10261/2814
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2814
dc.description We present a new dynamic force microscopy technique for imaging in liquids in the piconewton regime. The low quality factor (Q) of the cantilever is increased up to three orders of magnitude by the implementation of a positive feedback control. The technique also includes a phase-locked loop unit to track the resonance of the cantilever. Experiments and computer simulations indicate that the tip-sample forces are below 100 pN, about two orders of magnitude lower than in conventional tapping mode atomic force microscopy. Furthermore, the spectroscopic ability is greatly enhanced. Either the phase shift or the resonant frequency shows a high sensitivity to variations in either the energy dissipation or conservative interactions between the tip and the sample, respectively. The potential of this technique is demonstrated by imaging living cells.
dc.description Peer reviewed
dc.format 1287077 bytes
dc.format application/pdf
dc.language eng
dc.publisher Biophysical Society
dc.relation http://www.biophysj.org/cgi/content/full/81/1/526
dc.rights openAccess
dc.title High-Q dynamic force microscopy in liquid and its application to living cells
dc.type Artículo


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