أعرض تسجيلة المادة بشكل مبسط
| dc.creator |
Perona, Javier S. |
|
| dc.creator |
Avella, Michael |
|
| dc.creator |
Botham, K. M. |
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| dc.creator |
Ruiz-Gutiérrez, Valentina |
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| dc.date |
2008-01-22T16:37:34Z |
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| dc.date |
2008-01-22T16:37:34Z |
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| dc.date |
2008-01-22T16:37:34Z |
|
| dc.date.accessioned |
2017-01-31T00:59:45Z |
|
| dc.date.available |
2017-01-31T00:59:45Z |
|
| dc.identifier |
http://hdl.handle.net/10261/2729 |
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| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2729 |
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| dc.description |
Minor components from dietary oils can modulate the atherogenic response of the TAG-rich lipoproteins (TRL) in which they are transported. In
the present study we investigated the influence of TRL isolated from man after the intake of oleic acid-rich oils with different minor component
compositions on VLDL secretion by rat primary hepatocytes. TRL were isolated from nine men after the intake of meals enriched with high-oleic
sunflower oil (HOSO) or virgin olive oil (VOO) or VOO enriched with minor components (EVO). TRL were incubated with rat primary hepatocytes
and the lipid accumulation was analysed in the cells and the secreted VLDL. The expression of genes for proteins related to hepatic lipid
metabolism and VLDL production was also measured. Incubation of hepatocytes with TRL derived from HOSO as compared to VOO led to lower
intracellular lipid accumulation and VLDL production despite higher mRNA expression for diacylglycerol-acyltransferase, microsomal TAG transfer
protein, apoB and PPARa. When TRL derived from EVO were used there were no changes in VLDL secretion. These results suggest that
incorporation of minor components from dietary high-oleic oils into TRL modulates the effect of these atherogenic particles on VLDL secretion. |
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| dc.description |
Peer reviewed |
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| dc.format |
203366 bytes |
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| dc.format |
application/pdf |
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| dc.language |
eng |
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| dc.relation |
British Journal of Nutrition |
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| dc.relation |
99 (2008) 29-36 |
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| dc.rights |
openAccess |
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| dc.title |
Regulation of very-low-density lipoprotein secretion by minor components of oleic-acid rich oils |
|
| dc.type |
Artículo |
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أعرض تسجيلة المادة بشكل مبسط