المستودع الأكاديمي جامعة المدينة

Multifunctional genetic constructions having a high capacity to inhibit the expression of CCR5 on the cell surface

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dc.creator González de la Peña, Manuel Angel
dc.creator Serrano Gómez, Fernando
dc.creator Abad, José Luis
dc.creator Bernad, Antonio
dc.creator Llorente Gómez, María de las Mercedes
dc.creator Martínez-Alonso, Carlos
dc.creator Garmendia Mendizábal, Cristina
dc.date 2008-01-22T08:11:12Z
dc.date 2008-01-22T08:11:12Z
dc.date 2004-12-02
dc.date.accessioned 2017-01-31T00:59:45Z
dc.date.available 2017-01-31T00:59:45Z
dc.identifier International Publication Number: WO 2004/013330 A1
dc.identifier http://hdl.handle.net/10261/2724
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/2724
dc.description Filing Date: 2003-07-10.--Priority Data: ES P200201776 (2002-07-26)
dc.description The invention relates to multifunctional genetic constructions which can mimic the HIV-1-resistant phenotype in individuals with mutations that functionally inactivate the CCR5 chemokine receptor. In this way, the invention relates to various therapeutic genetic constructions which can inhibit specifically the expression of the aforementioned receptor in human cells and to retroviral vectors which can be used to introduce therapeutic genes into said cells. Moreover, the invention relates to a genetic transduction system based on the above-mentioned vectors with applications in experimental animal models and clinical treatments for HIV-1. The functional inactivation systems outlined herein can also be used to research and treat other human pathologies involving the CCR5 protein or other chemokine receptors.
dc.format 3780143 bytes
dc.format application/pdf
dc.language spa
dc.rights openAccess
dc.title Multifunctional genetic constructions having a high capacity to inhibit the expression of CCR5 on the cell surface
dc.title Construcciones genéticas multifuncionales con alta capacidad inhibitoria de la expresión de CCR5 en la superficie celular
dc.type Patente


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