| dc.creator |
Chiara, José Luis |
|
| dc.creator |
Storch, Isabel |
|
| dc.creator |
García, Ángela |
|
| dc.creator |
Bastida, Ágatha |
|
| dc.creator |
Bobo, Sofía |
|
| dc.creator |
Martín-Ortega, María D. |
|
| dc.date |
2007-11-12T11:11:00Z |
|
| dc.date |
2007-11-12T11:11:00Z |
|
| dc.date |
2004-11-08 |
|
| dc.date.accessioned |
2017-01-31T00:58:17Z |
|
| dc.date.available |
2017-01-31T00:58:17Z |
|
| dc.identifier |
ChemBioChem 6(1): 186-191 (2005) |
|
| dc.identifier |
10.1002/cbic.200400231 |
|
| dc.identifier |
http://hdl.handle.net/10261/1980 |
|
| dc.identifier |
10.1002/cbic.200400231 |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1980 |
|
| dc.description |
6 páginas, 2 figuras, 2 esquemas, 2 tablas.-- ChemBioChem Special Issue: EMBO Symposium: Chemistry Meets Biology. |
|
| dc.description |
A new trehazolin analogue, 1-thiatrehazolin, has been synthesized from carbohydrate precursors by a highly efficient route based on our previously developed ketone/oxime ether reductive carbocyclization reaction for the construction of the cyclitol ring and an intramolecular nucleophilic displacement reaction for the construction of the thiazoline ring. 1-Thiatrehazolin is a very potent, slow, tight-binding trehalase inhibitor. On the basis of the experimental results, a structural model for trehalase inhibition by trehazolin and analogues is proposed, supported by theoretical calculations. |
|
| dc.description |
Financial support by the Ministry of Science and Technology of Spain (project BQU2000-1501-C02-01) is gratefully acknowledged. |
|
| dc.description |
Peer reviewed |
|
| dc.language |
eng |
|
| dc.publisher |
John Wiley & Sons |
|
| dc.relation |
http://dx.doi.org/10.1002/cbic.200400231 |
|
| dc.rights |
openAccess |
|
| dc.subject |
Ab initio calculations |
|
| dc.subject |
Cyclitols |
|
| dc.subject |
Glycosidases |
|
| dc.subject |
Inhibitors |
|
| dc.subject |
Sulfur heterocycles |
|
| dc.title |
Synthesis, inhibition properties and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: Towards a structural understanding of trehazolin inhibition |
|
| dc.type |
Artículo |
|