المستودع الأكاديمي جامعة المدينة

SPOC: A widely distributed domain associated with cancer, apoptosis and transcription

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dc.creator Sánchez-Pulido, Luis
dc.creator Rojas, Ana Mª.
dc.creator Van Wely, Karel H. M.
dc.creator Martínez-Alonso, Carlos
dc.creator Valencia, Alfonso
dc.date 2007-05-08T16:15:48Z
dc.date 2007-05-08T16:15:48Z
dc.date 2004-07-08
dc.date.accessioned 2017-01-31T00:57:13Z
dc.date.available 2017-01-31T00:57:13Z
dc.identifier BMC Bioinformatics 2004, 5:91
dc.identifier 1471-2105
dc.identifier http://hdl.handle.net/10261/1444
dc.identifier 10.1186/1471-2105-5-91
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1444
dc.description This article is available from: http://www.biomedcentral.com/1471-2105/5/91
dc.description [Background] The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.
dc.description [Results] We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.
dc.description [Conclusions] The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
dc.description This study was financed in part by the VITH EU Framework Project QLGI-CT-2001-01536.
dc.description Peer reviewed
dc.language eng
dc.publisher BioMed Central
dc.relation Publisher’s version
dc.rights openAccess
dc.title SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
dc.type Artículo


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