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Is mammalian chromosomal evolution driven by regions of genome fragility?

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dc.creator Ruiz-Herrera, Aurora
dc.creator Castresana, José
dc.creator Robinson, Terence J
dc.date 2007-05-08T13:53:24Z
dc.date 2007-05-08T13:53:24Z
dc.date 2006-12-08
dc.date.accessioned 2017-01-31T00:57:10Z
dc.date.available 2017-01-31T00:57:10Z
dc.identifier Genome Biology 2006, 7:R115
dc.identifier 1465-6914
dc.identifier http://hdl.handle.net/10261/1423
dc.identifier 10.1186/gb-2006-7-12-r115
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1423
dc.description [Background] A fundamental question in comparative genomics concerns the identification of mechanisms that underpin chromosomal change. In an attempt to shed light on the dynamics of mammalian genome evolution, we analyzed the distribution of syntenic blocks, evolutionary breakpoint regions, and evolutionary breakpoints taken from public databases available for seven eutherian species (mouse, rat, cattle, dog, pig, cat, and horse) and the chicken, and examined these for correspondence with human fragile sites and tandem repeats.
dc.description [Results] Our results confirm previous investigations that showed the presence of chromosomal regions in the human genome that have been repeatedly used as illustrated by a high breakpoint accumulation in certain chromosomes and chromosomal bands. We show, however, that there is a striking correspondence between fragile site location, the positions of evolutionary breakpoints, and the distribution of tandem repeats throughout the human genome, which similarly reflect a non-uniform pattern of occurrence.
dc.description [Conclusion] These observations provide further evidence that certain chromosomal regions in the human genome have been repeatedly used in the evolutionary process. As a consequence, the genome is a composite of fragile regions prone to reorganization that have been conserved in different lineages, and genomic tracts that do not exhibit the same levels of evolutionary plasticity.
dc.description Peer reviewed
dc.language eng
dc.publisher BioMed Central
dc.relation Publisher’s version
dc.rights openAccess
dc.subject Comparative genomics
dc.subject Genome evolution
dc.subject Mammalian
dc.subject Eutherian species
dc.title Is mammalian chromosomal evolution driven by regions of genome fragility?
dc.type Artículo


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