المستودع الأكاديمي جامعة المدينة

Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus

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dc.creator Sánchez, Elena
dc.creator Sabio, José Mario
dc.creator Callejas-Rubio, J. L.
dc.creator Ramón, Enrique de
dc.creator García-Portales, Rosa
dc.creator García-Hernández, F. J.
dc.creator Jiménez-Alonso, Juan
dc.creator González-Escribano, M. F.
dc.creator Martín, J.
dc.creator Koeleman, B. P.
dc.date 2007-05-08T11:44:21Z
dc.date 2007-05-08T11:44:21Z
dc.date 2006-05-23
dc.date.accessioned 2017-01-31T00:57:07Z
dc.date.available 2017-01-31T00:57:07Z
dc.identifier BMC Medical Genetics 2006, 7:48
dc.identifier 1471-2350
dc.identifier http://hdl.handle.net/10261/1402
dc.identifier 10.1186/1471-2350-7-48
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10261/1402
dc.description This article is available from: http://www.biomedcentral.com/1471-2350/7/48
dc.description [Background] Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1α, and MCP-1 for systemic lupus erythematosus.
dc.description [Methods] The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8, IL-1α, and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay.
dc.description [Results] No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the RANTES, IL-8, IL-1α, and MCP-1 polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found.
dc.description [Conclusion] These results suggest that the tested functional variation of RANTES, IL-8, IL-1α, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population.
dc.description This work was supported by grant SAF03-3460 from Plan Nacional de I+D+I, and in part by the Junta de Andalucía, grupo CTS-180. We thank Sasha Zhernakova for her excellent technical assistance.
dc.description Peer reviewed
dc.language eng
dc.publisher BioMed Central
dc.relation Publisher’s version
dc.rights openAccess
dc.title Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
dc.type Artículo


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