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Factors Associated with Marburg Hemorrhagic Fever:

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dc.contributor Medecins Sans Frontieres–Spain and others
dc.creator Roddy, Paul
dc.creator Sara L Thomas
dc.creator Benjamin Jeffs
dc.creator Pascoal Nascimento Folo
dc.creator Pedro Pablo Palma
dc.creator Bengi Moco Henrique
dc.creator Luis Villa
dc.creator Fernando Paixao Damiao Machado
dc.creator Oscar Bernal
dc.creator Steven M. Jones
dc.creator James E. Strong
dc.creator Heinz Feldmann
dc.creator Matthias Borchert
dc.date 2010-06-15
dc.date.accessioned 2017-01-31T07:17:32Z
dc.date.available 2017-01-31T07:17:32Z
dc.identifier Roddy P, Thomas SL, Jeffs B, et al. Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. Journal of Infectious Diseases. 2010;201(12)1909-1918
dc.identifier 00221899
dc.identifier 15376613
dc.identifier 10.1086/652748
dc.identifier http://hdl.handle.net/10144/99154
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/99154
dc.identifier The Journal of Infectious Diseases
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/99154
dc.description Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
dc.language en
dc.publisher Infectious Disease Society of America
dc.rights Published by Infectious Diseases Society of America Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url]
dc.subject filovirus
dc.subject case definition
dc.title Factors Associated with Marburg Hemorrhagic Fever:
dc.type Article

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