| dc.contributor |
International Union against Tuberculosis and Lung Disease, Paris, France. adharries@theunion.org |
|
| dc.creator |
Harries, Anthony D |
|
| dc.creator |
Zachariah, Rony |
|
| dc.creator |
van Oosterhout, Joep J |
|
| dc.creator |
Reid, Steven D |
|
| dc.creator |
Hosseinipour, Mina C |
|
| dc.creator |
Arendt, Vic |
|
| dc.creator |
Chirwa, Zengani |
|
| dc.creator |
Jahn, Andreas |
|
| dc.creator |
Schouten, Erik J |
|
| dc.creator |
Kamoto, Kelita |
|
| dc.date |
2010-01 |
|
| dc.date.accessioned |
2017-01-31T07:16:25Z |
|
| dc.date.available |
2017-01-31T07:16:25Z |
|
| dc.identifier |
Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives. 2010, 10 (1):60-5 Lancet Infect Dis |
|
| dc.identifier |
1474-4457 |
|
| dc.identifier |
20129150 |
|
| dc.identifier |
10.1016/S1473-3099(09)70321-4 |
|
| dc.identifier |
http://hdl.handle.net/10144/95553 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/95553 |
|
| dc.identifier |
The Lancet Infectious Diseases |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/95553 |
|
| dc.description |
Despite the enormous progress made in scaling up antiretroviral therapy (ART) in sub-Saharan Africa, many challenges remain, not least of which are the identification and management of patients who have failed first-line therapy. Less than 3% of patients are receiving second-line treatment at present, whereas 15-25% of patients have detectable viral loads 12 months or more into treatment, of whom a substantial proportion might have virological failure. We discuss the reasons why virological ART failure is likely to be under-diagnosed in the routine health system, and address the current difficulties with standard recommended second-line ART regimens. The development of new diagnostic tools for ART failure, in particular a point-of-care HIV viral-load test, combined with simple and inexpensive second-line therapy, such as boosted protease-inhibitor monotherapy, could revolutionise the management of ART failure in resource-limited settings. |
|
| dc.language |
en |
|
| dc.rights |
Published by Elsevier
Reproduced on this site with permission of Elsevier Ltd. Please see [url]http://www.thelancet.com/journals/laninf[/url] for further relevant comment. |
|
| dc.title |
Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives. |
|