| dc.contributor |
Médecins Sans Frontières, Medical Department (Operational Research), Brussels Operational Center, 68 Rue de Gasperich, L-1617, Luxembourg. |
|
| dc.creator |
Harries, Katie |
|
| dc.creator |
Zachariah, Rony |
|
| dc.creator |
Manzi, Marcel |
|
| dc.creator |
Firmenich, Peter |
|
| dc.creator |
Mathela, Richard |
|
| dc.creator |
Drabo, Joseph |
|
| dc.creator |
Onadja, G |
|
| dc.creator |
Arnould, Line |
|
| dc.creator |
Harries, A D |
|
| dc.date |
2009-09-22 |
|
| dc.date.accessioned |
2017-01-31T07:16:14Z |
|
| dc.date.available |
2017-01-31T07:16:14Z |
|
| dc.identifier |
Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso. 2009: Trans. R. Soc. Trop. Med. Hyg. |
|
| dc.identifier |
1878-3503 |
|
| dc.identifier |
19783268 |
|
| dc.identifier |
10.1016/j.trstmh.2009.08.012 |
|
| dc.identifier |
http://hdl.handle.net/10144/91313 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/91313 |
|
| dc.identifier |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/91313 |
|
| dc.description |
In an urban district hospital in Burkina Faso we investigated the relative proportions of HIV-1, HIV-2 and HIV-1/2 among those tested, the baseline sociodemographic and clinical characteristics, and the response to and outcome of antiretroviral therapy (ART). A total of 7368 individuals (male=32%; median age=34 years) were included in the analysis over a 6 year period (2002-2008). The proportions of HIV-1, HIV-2 and dual infection were 94%, 2.5% and 3.6%, respectively. HIV-1-infected individuals were younger, whereas HIV-2-infected individuals were more likely to be male, have higher CD4 counts and be asymptomatic on presentation. ART was started in 4255 adult patients who were followed up for a total of 8679 person-years, during which time 469 deaths occurred. Mortality differences by serotype were not statistically significant, but were generally worse for HIV-2 and HIV-1/2 after controlling for age, CD4 count and WHO stage. Among severely immune-deficient patients, mortality was higher for HIV-2 than HIV-1. CD4 count recovery was poorest for HIV-2. HIV-2 and dually infected patients appeared to do less well on ART than HIV-1 patients. Reasons may include differences in age at baseline, lower intrinsic immune recovery in HIV-2, use of ineffective ART regimens (inappropriate prescribing) by clinicians, and poor drug adherence. |
|
| dc.language |
en |
|
| dc.rights |
Published by Elsevier
Archived on this site with the kind permission of Elsevier Ltd. ([url]http://www.sciencedirect.com/science/journal/00359203[/url]) and the Royal Society of Tropical Medicine and Hygiene ([url]http://www.rstmh.org/transactions.asp[/url]) |
|
| dc.title |
Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso. |
|