| dc.contributor |
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. |
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| dc.creator |
Stepniewska, K |
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| dc.creator |
Taylor, W R J |
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| dc.creator |
Mayxay, M |
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| dc.creator |
Price, R |
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| dc.creator |
Smithuis, F |
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| dc.creator |
Guthmann, J P |
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| dc.creator |
Barnes, K |
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| dc.creator |
Myint, H Y |
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| dc.creator |
Adjuik, M |
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| dc.creator |
Olliaro, P |
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| dc.creator |
Pukrittayakamee, S |
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| dc.creator |
Looareesuwan, S |
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| dc.creator |
Hien, T T |
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| dc.creator |
Farrar, J |
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| dc.creator |
Nosten, F |
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| dc.creator |
Day, N P J |
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| dc.creator |
White, N J |
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| dc.date |
2004-11 |
|
| dc.date.accessioned |
2017-01-31T07:13:54Z |
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| dc.date.available |
2017-01-31T07:13:54Z |
|
| dc.identifier |
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. 2004, 48 (11):4271-80 Antimicrob. Agents Chemother. |
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| dc.identifier |
0066-4804 |
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| dc.identifier |
15504852 |
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| dc.identifier |
10.1128/AAC.48.11.4271-4280.2004 |
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| dc.identifier |
http://hdl.handle.net/10144/56122 |
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| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/56122 |
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| dc.identifier |
Antimicrobial Agents and Chemotherapy |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/56122 |
|
| dc.description |
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003 were analyzed. These trials enrolled 13,772 patients, and participating patients comprised 23% of all patients enrolled in RCTs over the past 40 years; 61 (64%) trial arms were conducted in areas where the rate of malaria transmission was low, and 58 (50%) trial arms were supported by parasite genotyping to distinguish true recrudescences from reinfections. The median overall failure rate reported was 10% (range, 0 to 47%). The widely used day 14 assessment had a sensitivity of between 0 and 37% in identifying treatment failures and had no predictive value. Assessment at day 28 had a sensitivity of 66% overall (28 to 100% in individual trials) but could be used to predict the true failure rate if either parasite genotyping was performed (r(2) = 0.94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up. |
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| dc.language |
en |
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| dc.rights |
Published by American Society for Microbiology
Archived on this site with permission and copyright by the American Society for Microbiology |
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| dc.title |
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. |
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| dc.type |
Article |
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