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Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin.

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dc.contributor Epicentre, Paris, France.
dc.creator Dubray, C
dc.creator Ibrahim, S A
dc.creator Abdelmutalib, M
dc.creator Guerin, P J
dc.creator Dantoine, F
dc.creator Belanger, F
dc.creator Legros, D
dc.creator Pinoges, L
dc.creator Brown, V
dc.date 2008-03
dc.date.accessioned 2017-01-31T07:13:37Z
dc.date.available 2017-01-31T07:13:37Z
dc.identifier Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin. 2008, 28 (1):13-22notAnn Trop Paediatr
dc.identifier 0272-4936
dc.identifier 18318945
dc.identifier 10.1179/146532808X270635
dc.identifier http://hdl.handle.net/10144/52213
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/52213
dc.identifier Annals of Tropical Paediatrics
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/52213
dc.description BACKGROUND: Systemic antibiotics are routinely prescribed for severe acute malnutrition (SAM). However, there is no consensus regarding the most suitable regimen. In a therapeutic feeding centre in Khartoum, Sudan, a randomised, unblinded, superiority-controlled trial was conducted, comparing once daily intramuscular injection with ceftriaxone for 2 days with oral amoxicillin twice daily for 5 days in children aged 6-59 months with SAM. METHODS: Commencing with the first measured weight gain (WG) following admission, the risk difference and 95% confidence interval (95% CI) for children with a WG > or = 10 g/kg/day were calculated over a 14-day period. The recovery rate and case fatality ratio (CFR) between the two groups were also calculated. RESULTS: In an intention-to-treat analysis of 458 children, 53.5% (123/230) in the amoxicillin group and 55.7% (127/228, difference 2.2%, 95% CI -6.9-11.3) in the ceftriaxone group had a WG > or = 10 g/kg/day during a 14-day period. Recovery rate was 70% (161/230) in the amoxicillin group and 74.6% (170/228) in the ceftriaxone group (p=0.27). CFR was 3.9% (9/230) and 3.1% (7/228), respectively (p=0.67). Most deaths occurred within the 1st 2 weeks of admission. CONCLUSION: In the absence of severe complications, either ceftriaxone or amoxicillin is appropriate for malnourished children. However, in ambulatory programmes, especially where there are large numbers of admissions, ceftriaxone should facilitate the work of medical personnel.
dc.language en
dc.publisher Maney Publishing
dc.relation http://www.maney.co.uk/journals/atp
dc.rights Published by Maney Publishing Archived on this site with kind permission of Maney Publishing ([url]http://www.maney.co.uk/journals/atp[/url])
dc.title Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin.
dc.type Article

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