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The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.

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dc.contributor Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420/6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand. sue@tropmedres.ac
dc.creator Lee, S J
dc.creator Stepniewska, K
dc.creator Anstey, N
dc.creator Ashley, E
dc.creator Barnes, K
dc.creator Binh, T Q
dc.creator D'Alessandro, U
dc.creator Day, N
dc.creator de Vries, P J
dc.creator Dorsey, G
dc.creator Guthmann, J P
dc.creator Mayxay, M
dc.creator Newton, P
dc.creator Nosten, F
dc.creator Olliaro, P
dc.creator Osario, L
dc.creator Pinoges, L
dc.creator Price, R
dc.creator Rowland, M
dc.creator Smithuis, F
dc.creator Taylor, R
dc.creator White, N J
dc.date 2008-08
dc.date.accessioned 2017-01-31T07:13:35Z
dc.date.available 2017-01-31T07:13:35Z
dc.identifier The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. 2008, 7:149 Malar. J.
dc.identifier 1475-2875
dc.identifier 18673575
dc.identifier 10.1186/1475-2875-7-149
dc.identifier http://hdl.handle.net/10144/52033
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/52033
dc.identifier Malaria Journal
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/52033
dc.description BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.
dc.language en
dc.publisher BioMed Central
dc.relation http://www.malariajournal.com
dc.rights Published by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permission
dc.title The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.
dc.type Article


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