| dc.contributor |
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, South Africa. |
|
| dc.creator |
Coetzee, D |
|
| dc.creator |
Hildebrand, K |
|
| dc.creator |
Boulle, A |
|
| dc.creator |
Maartens, G |
|
| dc.creator |
Louis, F |
|
| dc.creator |
Labatala, V |
|
| dc.creator |
Reuter, H |
|
| dc.creator |
Ntwana, N |
|
| dc.creator |
Goemaere, E |
|
| dc.date |
2004-04-09 |
|
| dc.date.accessioned |
2017-01-31T07:12:30Z |
|
| dc.date.available |
2017-01-31T07:12:30Z |
|
| dc.identifier |
Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. 2004, 18 (6):887-95 AIDS |
|
| dc.identifier |
0269-9370 |
|
| dc.identifier |
15060436 |
|
| dc.identifier |
http://hdl.handle.net/10144/38956 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/38956 |
|
| dc.identifier |
AIDS (London, England) |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/38956 |
|
| dc.description |
BACKGROUND: A community-based antiretroviral therapy (ART) programme was established in 2001 in a South African township to explore the operational issues involved in providing ART in the public sector in resource-limited settings and demonstrate the feasibility of such a service. METHODS: Data was analysed on a cohort of patients with symptomatic HIV disease and a CD4 lymphocyte count < 200 x 10 cells/l. The programme used standardized protocols (using generic medicines whenever possible), a team-approach to clinical care and a patient-centred approach to promote adherence. RESULTS: Two-hundred and eighty-seven adults naive to prior ART were followed for a median duration of 13.9 months. The median CD4 lymphocyte count was 43 x 10 cells/l at initiation of treatment, and the mean log10 HIV RNA was 5.18 copies/ml. The HIV RNA level was undetectable (< 400 copies/ml) in 88.1, 89.2, 84.2, 75.0 and 69.7% of patients at 3, 6, 12, 18 and 24 months respectively. The cumulative probability of remaining alive was 86.3% at 24 months on treatment for all patients, 91.4% for those with a baseline CD4 lymphocyte count > or =50 x 10 cells/l, and 81.8% for those with a baseline CD4 lymphocyte count < 50 x 10 cells/l. The cumulative probability of changing a single antiretroviral drug by 24 months was 15.1% due to adverse events or contraindications, and 8.4% due to adverse events alone. CONCLUSIONS: ART can be provided in resource-limited settings with good patient retention and clinical outcomes. With responsible implementation, ART is a key component of a comprehensive response to the epidemic in those communities most affected by HIV. |
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| dc.language |
en |
|
| dc.rights |
Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer |
|
| dc.title |
Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. |
|