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How developing world concerns need to be part of drug development plans: A case study of four emerging antiretrovirals

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dc.contributor Médecins Sans Frontières, Campaign for Access to Essential Medecins, Geneva, Switzerland; Médecins Sans Frontières, Khayelitsha, South Africa; Geneva Teaching Hospital, Geneva, Switzerland
dc.creator van Roey, J
dc.creator von Schoen-Angerer, T
dc.creator Ford, N
dc.creator Calmy, A
dc.date 2008-07
dc.date.accessioned 2017-01-31T07:11:47Z
dc.date.available 2017-01-31T07:11:47Z
dc.identifier Drug Discov Today 2008;13(13-14):601-5
dc.identifier 1359-6446
dc.identifier 18598916
dc.identifier 10.1016/j.drudis.2008.04.009
dc.identifier http://hdl.handle.net/10144/37354
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/37354
dc.identifier Drug Discovery Today
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/37354
dc.description Clinical trials are usually designed to meet registration requirements in developed countries, and do not always address key concerns for use in developing countries. Four late-stage investigational new drugs - rilpivirine, etravirine, raltegravir and maraviroc - show potential to improve antiretroviral therapy. However, a number of issues could limit their use in developing countries, including dose selection, treatment strategy, combination with other drugs, use in specific populations and reliance on expensive tests. Key research questions relevant for developing countries need to be answered early in the drug development process to ensure maximum benefit for the majority.
dc.language en
dc.relation http://www.sciencedirect.com/science/journal/13596446
dc.rights Archived on this site by kind permission and copyright 2008 by Elsevier
dc.title How developing world concerns need to be part of drug development plans: A case study of four emerging antiretrovirals
dc.type Article


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