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Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).

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dc.contributor Swiss Tropical Institute, Basel.
dc.creator Schmid, C
dc.creator Richer, M
dc.creator Bilenge, C M M
dc.creator Josenando, T
dc.creator Chappuis, F
dc.creator Manthelot, C R
dc.creator Nangouma, A
dc.creator Doua, F
dc.creator Asumu, P
dc.creator Simarro, P
dc.creator Burri, C
dc.date 2005-06-01
dc.date.accessioned 2017-01-31T07:11:44Z
dc.date.available 2017-01-31T07:11:44Z
dc.identifier Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). 2005, 191 (11):1922-31 J. Infect. Dis.
dc.identifier 0022-1899
dc.identifier 15871127
dc.identifier 10.1086/429929
dc.identifier http://hdl.handle.net/10144/33073
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/33073
dc.identifier Journal of Infectious Diseases
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/33073
dc.description BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule. We demonstrate the effectiveness of this schedule in a noncontrolled, multinational drug-utilization study. METHODS: A total of 2020 patients with late-stage HAT were treated with the 10-day melarsoprol schedule in 16 centers in 7 African countries. We assessed outcome on the basis of major adverse events and the cure rate after treatment and during 2 years of follow-up. RESULTS: The cure rate 24 h after treatment was 93.9%; 2 years later, it was 86.2%. However, 49.3% of patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular eruptions was 0.8% and 6.8%, respectively. CONCLUSIONS: The 10-day treatment schedule was well implemented in the field and was effective. It reduces treatment duration, drug amount, and hospitalization costs per patient, and it increases treatment-center capacity. The shorter protocol has been recommended by the International Scientific Council for Trypanosomiasis Research and Control for the treatment of late-stage HAT caused by Trypanosoma brucei gambiense.
dc.language en
dc.publisher Infectious Diseases Society of America and University of Chicago Press
dc.relation http://www.journals.uchicago.edu/toc/jid
dc.rights Archived on this site with permission and copyright 2005 by the Infectious Diseases Society of America
dc.title Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).


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