DSpace Repository

Options for field diagnosis of human african trypanosomiasis.

Show simple item record

dc.contributor Travel and Migration Medicine Unit, Geneva University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. francois.chappuis@hcuge.ch
dc.creator Chappuis, F
dc.creator Loutan, L
dc.creator Simarro, P
dc.creator Lejon, V
dc.creator Büscher, P
dc.date 2005-01
dc.date.accessioned 2017-01-31T07:11:42Z
dc.date.available 2017-01-31T07:11:42Z
dc.identifier Options for field diagnosis of human african trypanosomiasis. 2005, 18 (1):133-46 Clin. Microbiol. Rev.
dc.identifier 0893-8512
dc.identifier 15653823
dc.identifier 10.1128/CMR.18.1.133-146.2005
dc.identifier http://hdl.handle.net/10144/33072
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/33072
dc.identifier Clinical Microbiology Reviews
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/33072
dc.description Human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense or T. b. rhodesiense remains highly prevalent in several rural areas of sub-Saharan Africa and is lethal if left untreated. Therefore, accurate tools are absolutely required for field diagnosis. For T. b. gambiense HAT, highly sensitive tests are available for serological screening but the sensitivity of parasitological confirmatory tests remains insufficient and needs to be improved. Screening for T. b. rhodesiense infection still relies on clinical features in the absence of serological tests available for field use. Ongoing research is opening perspectives for a new generation of field diagnostics. Also essential for both forms of HAT is accurate determination of the disease stage because of the high toxicity of melarsoprol, the drug most widely used during the neurological stage of the illness. Recent studies have confirmed the high accuracy of raised immunoglobulin M levels in the cerebrospinal fluid for the staging of T. b. gambiense HAT, and a promising simple assay (LATEX/IgM) is being tested in the field. Apart from the urgent need for better tools for the field diagnosis of this neglected disease, improved access to diagnosis and treatment for the population at risk remains the greatest challenge for the coming years.
dc.language en
dc.publisher The American Society for Microbiology
dc.rights Archived on this site with kind permission from the American Society for Microbiology
dc.title Options for field diagnosis of human african trypanosomiasis.

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account