DSpace Repository

Risk factors of visceral leishmaniasis in East Africa: a case-control study in Pokot territory of Kenya and Uganda

Show simple item record

dc.contributor Malaria Consortium Africa, Kampala, Uganda. Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London UK. Clinical Trials Area, Westat, Rockville, MD, USA. Médecins Sans Frontières, Geneva, Switzerland. Vector Control Division, Ministry of Health, Kampala, Uganda.
dc.creator Kolaczinski, J H
dc.creator Reithinger, R
dc.creator Worku, D
dc.creator Ocheng, A
dc.creator Kasimiro, J
dc.creator Kabatereine, N
dc.creator Brooker, S
dc.date 2008-01-09
dc.date.accessioned 2017-01-31T07:11:32Z
dc.date.available 2017-01-31T07:11:32Z
dc.identifier Int J Epidemiol 2008;37(2):344-52
dc.identifier 1464-3685
dc.identifier 18184669
dc.identifier 10.1093/ije/dym275
dc.identifier http://hdl.handle.net/10144/30093
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/30093
dc.identifier International Journal of Epidemiology
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/30093
dc.description BACKGROUND: In East Africa, visceral leishmaniasis (VL) is endemic in parts of Sudan, Ethiopia, Somalia, Kenya and Uganda. It is caused by Leishmania donovani and transmitted by the sandfly vector Phlebotomus martini. In the Pokot focus, reaching from western Kenya into eastern Uganda, formulation of a prevention strategy has been hindered by the lack of knowledge on VL risk factors as well as by lack of support from health sector donors. The present study was conducted to establish the necessary evidence-base and to stimulate interest in supporting the control of this neglected tropical disease in Uganda and Kenya. METHODS: A case-control study was carried out from June to December 2006. Cases were recruited at Amudat hospital, Nakapiripirit district, Uganda, after clinical and parasitological confirmation of symptomatic VL infection. Controls were individuals that tested negative using a rK39 antigen-based dipstick, which were recruited at random from the same communities as the cases. Data were analysed using conditional logistic regression. RESULTS: Ninety-three cases and 226 controls were recruited into the study. Multivariate analysis identified low socio-economic status and treating livestock with insecticide as risk factors for VL. Sleeping near animals, owning a mosquito net and knowing about VL symptoms were associated with a reduced risk of VL. CONCLUSIONS: VL affects the poorest of the poor of the Pokot tribe. Distribution of insecticide-treated mosquito nets combined with dissemination of culturally appropriate behaviour-change education is likely to be an effective prevention strategy.
dc.language en
dc.relation http://ije.oxfordjournals.org/cgi/content/abstract/dym275v1
dc.rights Published by Oxford University Press. Archived on this site with kind permission from Oxford University Press and the International Epidemiological Association
dc.title Risk factors of visceral leishmaniasis in East Africa: a case-control study in Pokot territory of Kenya and Uganda
dc.type Article

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account