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Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

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dc.contributor Medecins sans Frontières (MSF), Max Euweplein 40, 1001, EA, Amsterdam, The Netherlands.
dc.creator Graupner, J
dc.creator Göbels, K
dc.creator Grobusch, M P
dc.creator Lund, A
dc.creator Richter, J
dc.creator Häussinger, D
dc.date 2005-06
dc.date.accessioned 2017-01-31T07:10:47Z
dc.date.available 2017-01-31T07:10:47Z
dc.identifier Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine. 2005, 96 (3):162-5 Parasitol. Res.
dc.identifier 0932-0113
dc.identifier 15864651
dc.identifier 10.1007/s00436-005-1325-7
dc.identifier http://hdl.handle.net/10144/23763
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/23763
dc.identifier Parasitology Research
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/23763
dc.description Falciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (+/-1.9) and more pronounced in children with anaemia<10 g/dl on enrollment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.
dc.language en
dc.rights Archived on this site with kind permission of Springer Science+Business Media
dc.title Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.


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