| dc.contributor |
Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. dcoetzee@phfm.uct.ac.za |
|
| dc.creator |
Coetzee, D |
|
| dc.creator |
Hilderbrand, K |
|
| dc.creator |
Boulle, A |
|
| dc.creator |
Draper, B |
|
| dc.creator |
Abdullah, F |
|
| dc.creator |
Goemaere, E |
|
| dc.date |
2005-07 |
|
| dc.date.accessioned |
2017-01-31T07:10:32Z |
|
| dc.date.available |
2017-01-31T07:10:32Z |
|
| dc.identifier |
Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. 2005, 83 (7):489-94 Bull. World Health Organ. |
|
| dc.identifier |
0042-9686 |
|
| dc.identifier |
16175822 |
|
| dc.identifier |
http://hdl.handle.net/10144/22392 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/22392 |
|
| dc.identifier |
Bulletin of the World Health Organization |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/22392 |
|
| dc.description |
OBJECTIVE: The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict of Khayelitsha. METHODS: A consecutive sample of 658 mother-infant pairs, identified from the PMTCT register from 1 March to 30 November 2003, were identified for enrolment in this study. Details of the regimen received were established and HIV status of the infants at between 6 and 10 weeks of age was determined by qualitative DNA polymerase chain reaction. Zidovudine (AZT) was provided antenatally from week 34 of gestation and during labour. Infant formula milk was-offered to mothers who chose not to breastfeed. The protocol was amended in July 2003 such that women who had received < 2 weeks of treatment with AZT were given a single dose of nevirapine (NVP) at the onset of labour, and the infant received a weight-adjusted dose of NVP within 72 h of delivery. RESULTS: Of the 535 mother-infant pairs (81%) eventually included in the study, 410 (77%) received an effective PMTCT intervention according to the protocol. The rate of transmission of HIV from mother to child was 8.8% (95% confidence interval (CI), 6.2-10.9). A maternal age of > 25 years was the only significant independent risk factor for transmission (odds ratio, 2.12; 95% CI, 1.14-4.07). CONCLUSION: The results of this study demonstrate the feasibility and effectiveness of a large-scale PMTCT programme in an urban public-sector setting. |
|
| dc.language |
en |
|
| dc.publisher |
WHO |
|
| dc.rights |
Archived with thanks to the World Health Organization |
|
| dc.title |
Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. |
|