أعرض تسجيلة المادة بشكل مبسط
| dc.contributor |
Institut National de la Santé et de la Recherche Médicale SC4, Faculté de Médecine, St. Antoine Université Pierre et Marie Curie, Paris, France; Epicentre, Paris, France. |
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| dc.creator |
Tassie, J M |
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| dc.creator |
Grabar, S |
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| dc.creator |
Lancar, R |
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| dc.creator |
Deloumeaux, J |
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| dc.creator |
Bentata, M |
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| dc.creator |
Costagliola, D |
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| dc.date |
2002-05-01 |
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| dc.date.accessioned |
2017-01-31T07:10:31Z |
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| dc.date.available |
2017-01-31T07:10:31Z |
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| dc.identifier |
Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection. 2002, 30 (1):81-7 J. Acquir. Immune Defic. Syndr. |
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| dc.identifier |
1525-4135 |
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| dc.identifier |
12048367 |
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| dc.identifier |
http://hdl.handle.net/10144/22253 |
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| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/22253 |
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| dc.identifier |
Journal of Acquired Immune Deficiency Syndromes (1999) |
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| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/22253 |
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| dc.description |
To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors. |
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| dc.language |
en |
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| dc.rights |
Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer |
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| dc.title |
Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection. |
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أعرض تسجيلة المادة بشكل مبسط