| dc.contributor |
Medecins Sans Frontieres-Holland, Amsterdam. |
|
| dc.creator |
Seaman, J |
|
| dc.creator |
Pryce, D |
|
| dc.creator |
Sondorp, H |
|
| dc.creator |
Moody, A |
|
| dc.creator |
Bryceson, A |
|
| dc.creator |
Davidson, R N |
|
| dc.date |
1993-09 |
|
| dc.date.accessioned |
2017-01-31T07:10:30Z |
|
| dc.date.available |
2017-01-31T07:10:30Z |
|
| dc.identifier |
Epidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone. 1993, 168 (3):715-20 J. Infect. Dis. |
|
| dc.identifier |
0022-1899 |
|
| dc.identifier |
8394861 |
|
| dc.identifier |
http://hdl.handle.net/10144/22252 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/22252 |
|
| dc.identifier |
The Journal of Infectious Diseases |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/22252 |
|
| dc.description |
In a comparative trial of treatment in southern Sudan, visceral leishmaniasis was diagnosed by the following symptoms: fever for > 1 month, splenomegaly, and antileishmanial direct agglutination test (DAT) titer of > or = 1:25,600. Patients (200) were randomized to receive sodium stibogluconate (Sbv) at 20 mg/kg/day for 30 days (groups S, n = 99) or Sbv at 20 mg/kg/day plus aminosidine at 15 mg/kg/day for 17 days (group AS, n = 101). Of 192 patients who had spleens or lymph nodes aspirated at entry, 134 (70%) were positive for parasites. During treatment, 7% in group S and 4% in group AS died. All 184 patients who completed treatment were clinically cured. At days 15-17, microscopy of aspirates showed that 57 (95%) of 60 in group AS were negative for parasites compared with 47 (81%) of 58 in group S (P = .018). At day 30, 57 (93.4%) of 61 group S aspirates were negative. |
|
| dc.language |
en |
|
| dc.publisher |
Published by Infectious Diseases Society of America |
|
| dc.relation |
http://www.journals.uchicago.edu/toc/jid |
|
| dc.rights |
Archived on this site with permission and copyright 200X by the Infectious Diseases Society of America |
|
| dc.title |
Epidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone. |
|