المستودع الأكاديمي جامعة المدينة

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand.

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dc.contributor Mahidol - Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. nickw@tropmedres.ac.
dc.creator Tarning, J
dc.creator Ashley, E A
dc.creator Lindegardh, N
dc.creator Stepniewska, K
dc.creator Phaiphun, L
dc.creator Day, N P J
dc.creator McGready, R
dc.creator Ashton, M
dc.creator Nosten, F
dc.creator White, N J
dc.date 2008-03
dc.date.accessioned 2017-01-31T07:10:17Z
dc.date.available 2017-01-31T07:10:17Z
dc.identifier Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand. 2008, 52 (3):1052-61 Antimicrob. Agents Chemother.
dc.identifier 0066-4804
dc.identifier 18180343
dc.identifier 10.1128/AAC.00955-07
dc.identifier http://hdl.handle.net/10144/19920
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/19920
dc.identifier Antimicrobial Agents and Chemotherapy
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/19920
dc.description The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-piperaquine were characterized. Piperaquine pharmacokinetics in 98 Burmese and Karen patients aged 3 to 55 years were described by a two-compartment disposition model with first-order absorption and interindividual random variability on all parameters and were similar with the three- and four-dose regimens. Children had a lower body weight-normalized oral clearance than adults, resulting in longer terminal elimination half-lives and higher total exposure to piperaquine (area under the concentration-time curve from 0 to 63 days [AUC(day 0-63)]). However, children had lower plasma concentrations in the therapeutically relevant posttreatment prophylactic period (AUC(day 3-20)) because of smaller body weight-normalized central volumes of distribution and shorter distribution half-lives. Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults.
dc.language en
dc.publisher American Society for Microbiology
dc.rights Archived with thanks and copyright by the American Society for Microbiology
dc.title Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand.


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