| dc.contributor |
Medical Department (Operational Research), Médecins sans Frontières, Brussels Operational Centre, Luxembourg. zachariah@internet.lu |
|
| dc.creator |
Zachariah, R |
|
| dc.creator |
Fitzgerald, M |
|
| dc.creator |
Massaquoi, M |
|
| dc.creator |
Acabu, A |
|
| dc.creator |
Chilomo, D |
|
| dc.creator |
Salaniponi, F M L |
|
| dc.creator |
Harries, A D |
|
| dc.date |
2007-08 |
|
| dc.date.accessioned |
2017-01-31T07:10:13Z |
|
| dc.date.available |
2017-01-31T07:10:13Z |
|
| dc.identifier |
Does Antiretroviral Treatment Reduce Case Fatality Among HIV-Positive Patients with Tuberculosis in Malawi? 2007, 11 (8):848-53 Int. J. Tuberc. Lung Dis. |
|
| dc.identifier |
1027-3719 |
|
| dc.identifier |
17705949 |
|
| dc.identifier |
http://hdl.handle.net/10144/19396 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/19396 |
|
| dc.identifier |
International Journal of Tuberculosis and Lung Disease |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/19396 |
|
| dc.description |
SETTING: Thyolo district, Malawi. OBJECTIVES: To report on 1) case fatality among human immunodeficiency virus (HIV) positive tuberculosis (TB) patients while on anti-tuberculosis treatment and 2) whether antiretroviral treatment (ART) initiated during the continuation phase of TB treatment reduces case fatality. DESIGN: Retrospective cohort analysis. METHODS: Comparative analysis of treatment outcomes for TB patients registered between January and December 2004. RESULTS: Of 983 newly registered TB patients receiving diagnostic HIV testing, 658 (67%) were HIV-positive. A total of 132 (20%) patients died during the 8-month course of anti-tuberculosis treatment, of whom 82 (62%) died within the first 2 months of treatment when ART was not provided (cumulative incidence 3.0, 95%CI 2.5-3.6 per 100 person-years). A total of 576 TB patients started the continuation phase of anti-tuberculosis treatment, 180 (31%) of whom were started on ART. The case-fatality rate per 100 person-years was not significantly different for patients on ART (1.0, 95%CI 0.6-1.7) and those without ART (1.2, 95%CI 0.9-1.7, adjusted hazard ratio 0.86, 95%CI 0.4-1.6, P = 0.6) CONCLUSIONS: ART provided in the continuation phase of TB treatment does not have a significant impact on reducing case fatality. Reasons for this and possible measures to reduce high case fatality in the initial phase of TB treatment are discussed. |
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| dc.language |
en |
|
| dc.relation |
http://www.ingentaconnect.com/content/iuatld/ijtld |
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| dc.rights |
Archived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.org |
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| dc.title |
Does Antiretroviral Treatment Reduce Case Fatality Among HIV-Positive Patients with Tuberculosis in Malawi? |
|