المستودع الأكاديمي جامعة المدينة

Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis.

أعرض تسجيلة المادة بشكل مبسط

dc.contributor Epicentre, Paris, France.
dc.creator Pécoul, B
dc.creator Varaine, F
dc.creator Keita, M
dc.creator Soga, G
dc.creator Djibo, A
dc.creator Soula, G
dc.creator Abdou, A
dc.creator Etienne, J
dc.creator Rey, M
dc.date 1991-10-05
dc.date.accessioned 2017-01-31T07:10:13Z
dc.date.available 2017-01-31T07:10:13Z
dc.identifier Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis. 1991, 338 (8771):862-6 Lancet
dc.identifier 0140-6736
dc.identifier 1681224
dc.identifier http://hdl.handle.net/10144/19393
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/19393
dc.identifier Lancet
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/19393
dc.description In most developing countries, bacterial meningitis (BM) is associated with a high case-fatality rate. The search for a simple, convenient, and inexpensive antibiotic treatment remains a priority. In this study, a non-blinded, multicentre, randomised clinical trial of 528 cases of BM was done in two hospitals in Mali and Niger, between March, 1989, and May, 1990, to see whether a double injection of long-acting chloramphenicol (on admission to hospital and 48 h later) is as effective as a course of intravenous ampicillin (8 days, 4 times a day). The cumulative case-fatality rate on day 4 (principal end-point) among the chloramphenicol (254 patients) and ampicillin (274) groups were, respectively, 28% and 24.5% (relative risk 1.14, 95% confidence interval 0.86-1.52). No outbreak occurred during the study period. The hospital case-fatality rate was 33.1%. Main risk factors for death were associated with clinical condition on admission--ie, altered consciousness, convulsions, or dehydration. The case-fatality rates were 13% (21/161) for Neisseria meningitidis, 36.1% (48/133) for Haemophilus influenzae, and 67% (77/115) for Streptococcus pneumoniae. In a multiple logistic regression model, controlling for the differential distribution of potential risk factors (including bacterial species), there was no difference between treatment groups. Our findings suggest that long-acting chloramphenicol is a useful first-line presumptive treatment for BM in high-incidence countries.
dc.language en
dc.publisher Elsevier
dc.relation http://www.thelancet.com
dc.rights Reproduced on this site with permission of Elsevier Ltd. Please see www.thelancet.com for further relevant comment.
dc.title Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis.


الملفات في هذه المادة

الملفات الحجم الصيغة عرض

لا توجد أي ملفات مرتبطة بهذه المادة.

هذه المادة تبدو في المجموعات التالية:

أعرض تسجيلة المادة بشكل مبسط