| dc.contributor |
Médecins Sans Frontières, Cape Town, South Africa. |
|
| dc.creator |
Saranchuk, P |
|
| dc.creator |
Boulle, A |
|
| dc.creator |
Hilderbrand, K |
|
| dc.creator |
Coetzee, D |
|
| dc.creator |
Bedelu, M |
|
| dc.creator |
Van Cutsem, G |
|
| dc.creator |
Meintjes, G |
|
| dc.date |
2007-07 |
|
| dc.date.accessioned |
2017-01-31T07:09:58Z |
|
| dc.date.available |
2017-01-31T07:09:58Z |
|
| dc.identifier |
Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIV-infected adults. 2007, 97 (7):517-23 S. Afr. Med. J. |
|
| dc.identifier |
0256-9574 |
|
| dc.identifier |
17805454 |
|
| dc.identifier |
http://hdl.handle.net/10144/18372 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18372 |
|
| dc.identifier |
South African Medical Journal |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18372 |
|
| dc.description |
OBJECTIVES: To evaluate the diagnostic accuracy of and reduction in diagnostic delay attributable to a clinical algorithm used for the diagnosis of smear-negative pulmonary tuberculosis (SNPTB) in HIV-infected adults. DESIGN: An algorithm was designed to facilitate clinicoradiological diagnosis of pulmonary TB (PTB) in HIV-infected smear-negative adult patients. A folder review was performed on the first 58 cases referred for empirical TB treatment using this algorithm. SETTING: Nolungile HIV Clinic, Site C, Khayelitsha. SUBJECTS: Subjects included 58 HIV-infected adult patients with suspected PTB consecutively referred to the local TB clinic for outpatient TB treatment using this algorithm between 12 February 2004 and 30 April 2005. OUTCOME MEASURES: Outcome measures were response of C-reactive protein, haemoglobin, weight and symptoms to TB treatment, and TB culture result. Diagnostic delay (in days) was calculated. RESULTS: Thirty-two of the 58 patients (55%) had positive TB cultures (definite TB). Initiation of TB treatment occurred on average 19.5 days before the positive culture report. A further 21 patients (36%) demonstrated clinical improvement on empirical treatment (probable/possible TB). Two patients did not improve and subsequently died without a definitive diagnosis. Three patients defaulted treatment. CONCLUSIONS: SNPTB is more common in HIV-infected patients and leads to diagnostic delay. This algorithm allowed for earlier initiation of TB treatment in HIV-infected patients presenting with symptoms of PTB and negative smears or nonproductive cough in a high TB incidence setting. |
|
| dc.language |
en |
|
| dc.publisher |
Health and Medical Publishing Group |
|
| dc.relation |
http://www.samj.org.za |
|
| dc.rights |
Archived on this site with kind permission of the Health and Medical Publishing Group and the South African Medical Association. |
|
| dc.title |
Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIV-infected adults. |
|