| dc.contributor |
Epicentre, Paris, France. |
|
| dc.creator |
Fogg, C |
|
| dc.creator |
Bajunirwe, F |
|
| dc.creator |
Piola, P |
|
| dc.creator |
Biraro, S |
|
| dc.creator |
Checchi, F |
|
| dc.creator |
Kiguli, J |
|
| dc.creator |
Namiiro, P |
|
| dc.creator |
Musabe, J |
|
| dc.creator |
Kyomugisha, A |
|
| dc.creator |
Guthmann, J P |
|
| dc.date |
2004-11 |
|
| dc.date.accessioned |
2017-01-31T07:10:00Z |
|
| dc.date.available |
2017-01-31T07:10:00Z |
|
| dc.identifier |
Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. 2004, 71 (5):525-30 Am. J. Trop. Med. Hyg. |
|
| dc.identifier |
0002-9637 |
|
| dc.identifier |
15569777 |
|
| dc.identifier |
http://hdl.handle.net/10144/18355 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18355 |
|
| dc.identifier |
American Journal of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18355 |
|
| dc.description |
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its latest World Health Organization blister formulation. Patients with uncomplicated Plasmodium falciparum malaria were prescribed artemether-lumefantrine and received an explanation of how to take the following five doses at home. A tablet count was made and a questionnaire was completed during a home visit. Among 210 analyzable patients, 21 (10.0%) were definitely or probably non-adherent, whereas 189 (90.0%) were probably adherent. Age group was not associated with adherence. Lack of formal education was the only factor associated with non-adherence after controlling for confounders (odds ratio = 3.1, 95% confidence interval [CI] = 1.1-9.7). Mean lumefantrine blood levels were lower among non-adherent (n = 16) (2.76 microg/mL, 95% CI = 1.06-4.45) than among adherent (n = 171) (3.19 microg/mL, 95% CI = 2.84-3.54) patients, but this difference was not statistically significant. The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations. |
|
| dc.language |
en |
|
| dc.publisher |
Published by: American Society of Tropical Medicine and Hygiene |
|
| dc.relation |
http://www.ajtmh.org |
|
| dc.rights |
Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene,www.astmh.org |
|
| dc.title |
Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. |
|