| dc.contributor |
Epicentre, Paris, France. epimail@epicentre.msf.org |
|
| dc.creator |
Kaninda, A V |
|
| dc.creator |
Legros, D |
|
| dc.creator |
Jataou, I M |
|
| dc.creator |
Malfait, P |
|
| dc.creator |
Maisonneuve, M |
|
| dc.creator |
Paquet, C |
|
| dc.creator |
Moren, A |
|
| dc.date |
1998-11 |
|
| dc.date.accessioned |
2017-01-31T07:09:58Z |
|
| dc.date.available |
2017-01-31T07:09:58Z |
|
| dc.identifier |
Measles vaccine effectiveness in standard and early immunization strategies, Niger, 1995. 1998, 17 (11):1034-9 Pediatr. Infect. Dis. J. |
|
| dc.identifier |
0891-3668 |
|
| dc.identifier |
9849988 |
|
| dc.identifier |
http://hdl.handle.net/10144/18298 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18298 |
|
| dc.identifier |
The Pediatric Infectious Disease Journal |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18298 |
|
| dc.description |
BACKGROUND: An Expanded Programme on Immunization was started in late 1987 in Niger, including vaccination against measles with one dose of standard titer Schwarz vaccine given to infants after 9 months of age. During epidemics an early two-dose strategy was implemented (one dose between 6 and 8 months and one dose after 9 months). From January 1, 1995, until May 7, 1995, 13 892 measles cases were reported in Niamey, Niger. METHODS: A retrospective cohort study was conducted in a crowded area of Niamey at the end of the outbreak to assess the effectiveness of measles vaccine in standard (after 9 months) and early (before 9 months) immunization strategies under field conditions. RESULTS: Highest measles incidence rates were observed among children <1 year of age. Vaccine effectiveness estimates increased with age at vaccination from 78% with a single dose administered at 6 months of age to 95% at 9 months. Vaccine effectiveness with the early two dose strategy was 93%. CONCLUSIONS: Immunization with a single dose of standard titer Schwarz vaccine before 9 months of age provided higher clinical protection than expected from seropositivity studies. The early two dose strategy is justified in contexts where measles incidence is high before 9 months of age. Our results raise the issue of lowering the recommended age for measles vaccination in developing countries. |
|
| dc.language |
en |
|
| dc.rights |
Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer |
|
| dc.title |
Measles vaccine effectiveness in standard and early immunization strategies, Niger, 1995. |
|