| dc.contributor |
Medecins sans Frontieres, Operational Research, Brussels Operational Center, Belgium. zachariah@internet.lu |
|
| dc.creator |
Zachariah, R |
|
| dc.creator |
Fitzgerald, M |
|
| dc.creator |
Massaquoi, M |
|
| dc.creator |
Pasulani, O |
|
| dc.creator |
Arnould, L |
|
| dc.creator |
Makombe, S D |
|
| dc.creator |
Harries, A D |
|
| dc.date |
2006-11-28 |
|
| dc.date.accessioned |
2017-01-31T07:09:56Z |
|
| dc.date.available |
2017-01-31T07:09:56Z |
|
| dc.identifier |
Risk Factors for High Early Mortality in Patients on Antiretroviral Treatment in a Rural District of Malawi. 2006, 20 (18):2355-60 AIDS |
|
| dc.identifier |
0269-9370 |
|
| dc.identifier |
17117022 |
|
| dc.identifier |
10.1097/QAD.0b013e32801086b0 |
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| dc.identifier |
http://hdl.handle.net/10144/18297 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18297 |
|
| dc.identifier |
AIDS (London, England) |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18297 |
|
| dc.description |
OBJECTIVES: Among adults started on antiretroviral treatment (ART) in a rural district hospital (a) to determine the cumulative proportion of deaths that occur within 3 and 6 months of starting ART, and (b) to identify risk factors that may be associated with such mortality. DESIGN AND SETTING: A cross-sectional analytical study set in Thyolo district, Malawi. METHODS: Over a 2-year period (April 2003 to April 2005) mortality within the first 3 and 6 months of starting ART was determined and risk factors were examined. RESULTS: A total of 1507 individuals (517 men and 990 women), whose median age was 35 years were included in the study. There were a total of 190 (12.6%) deaths on ART of which 116 (61%) occurred within the first 3 months (very early mortality) and 150 (79%) during the first 6 months of initiating ART. Significant risk factors associated with such mortality included WHO stage IV disease, a baseline CD4 cell count under 50 cells/mul and increasing grades of malnutrition. A linear trend in mortality was observed with increasing grades of malnutrition (chi for trend = 96.1, P </= 0.001) and decreasing CD4 cell counts (chi for trend = 72.4, P </= 0.001). Individuals who were severely malnourished [body mass index (BMI) < 16.0 kg/m] had a six times higher risk of dying in the first 3 months than those with a normal nutritional status. CONCLUSIONS: Among individuals starting ART, the BMI and clinical staging could be important screening tools for use to identify and target individuals who, despite ART, are still at a high risk of early death. |
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| dc.language |
en |
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| dc.rights |
Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer |
|
| dc.title |
Risk Factors for High Early Mortality in Patients on Antiretroviral Treatment in a Rural District of Malawi. |
|