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WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.

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dc.contributor Médecins sans Frontières-Luxembourg, Thyolo, Malawi.
dc.creator Teck, R
dc.creator Ascurra, O
dc.creator Gomani, P
dc.creator Manzi, M
dc.creator Pasulani, O
dc.creator Kusamale, J
dc.creator Salaniponi, F M L
dc.creator Humblet, P
dc.creator Nunn, P
dc.creator Scano, F
dc.creator Harries, A D
dc.creator Zachariah, R
dc.date 2005-03
dc.date.accessioned 2017-01-31T07:09:49Z
dc.date.available 2017-01-31T07:09:49Z
dc.identifier WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts. 2005, 9 (3):258-62 Int. J. Tuberc. Lung Dis.
dc.identifier 1027-3719
dc.identifier 15786887
dc.identifier http://hdl.handle.net/10144/18292
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/18292
dc.identifier International Journal of Tuberculosis and Lung Disease
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18292
dc.description SETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV and patients with active and previous tuberculosis (TB). DESIGN: Cross-sectional study. METHODS: CD4 lymphocyte counts were determined in all consecutive HIV-positive individuals presenting to the antiretroviral clinic in WHO Stage III and IV. RESULTS: A CD4 lymphocyte count of < or = 350 cells/microl was found in 413 (90%) of 457 individuals in WHO Stage III and IV, 96% of 77 individuals with active TB, 92% of 65 individuals with a history of pulmonary TB (PTB) in the last year, 91% of 89 individuals with a previous history of PTB beyond 1 year, 81% of 32 individuals with a previous history of extra-pulmonary TB, 93% of 107 individuals with active or past TB with another HIV-related disease and 89% of 158 individuals with active or past TB without another HIV-related disease. CONCLUSIONS: In our setting, nine of 10 HIV-positive individuals presenting in WHO Stage III and IV and with active or previous TB have CD4 counts of < or = 350 cells/microl. It would thus be reasonable, in this or similar settings where CD4 counts are unavailable for clinical management, for all such patients to be considered eligible for antiretroviral therapy.
dc.language en
dc.publisher International Union Against TB and Lung Disease
dc.relation http://www.ingentaconnect.com/content/iuatld/ijtld
dc.rights Archived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.org
dc.title WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.


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