أعرض تسجيلة المادة بشكل مبسط
| dc.contributor |
Medecins Sans Frontieres-Luxembourg, Blantyre, Malawi. zachariah@internet.Lu |
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| dc.creator |
Zachariah, R |
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| dc.creator |
Spielmann M P |
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| dc.creator |
Chinji, C |
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| dc.creator |
Gomani, P |
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| dc.creator |
Arendt, V |
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| dc.creator |
Hargreaves, N J |
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| dc.creator |
Salaniponi, F M L |
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| dc.creator |
Harries, A D |
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| dc.date |
2003-05-02 |
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| dc.date.accessioned |
2017-01-31T07:09:49Z |
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| dc.date.available |
2017-01-31T07:09:49Z |
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| dc.identifier |
Voluntary Counselling, HIV Testing and Adjunctive Cotrimoxazole Reduces Mortality in Tuberculosis Patients in Thyolo, Malawi. 2003, 17 (7):1053-61 AIDS |
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| dc.identifier |
0269-9370 |
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| dc.identifier |
12700456 |
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| dc.identifier |
10.1097/01.aids.0000060355.78202.b7 |
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| dc.identifier |
http://hdl.handle.net/10144/18280 |
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| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18280 |
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| dc.identifier |
AIDS (London, England) |
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| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18280 |
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| dc.description |
OBJECTIVES: To assess the feasibility and effectiveness of voluntary counselling, HIV testing and adjunctive cotrimoxazole in reducing mortality in a cohort of tuberculosis (TB) patients registered under routine programme conditions in a rural district of Malawi. DESIGN: 'Before' and 'after' cohort study using historical controls. METHODS: Between 1 July 1999 and 30 June 2000 all TB patients were started on standardized anti-TB treatment, and offered voluntary counselling and HIV testing (VCT). Those found to be HIV-positive were offered cotrimoxazole at a dose of 480 mg twice daily, provided there were no contraindications. Side-effects were monitored clinically. End-of-treatment outcomes in this cohort (intervention group) were compared with a cohort registered between 1 July 1998 and 30 June 1999 in whom VCT and cotrimoxazole was not offered (control group). FINDINGS: A total of 1986 patients was registered in the study: 1061 in the intervention group and 925 in the control cohort. In the intervention group, 1019 (96%) patients were counselled pre-test, 964 (91%) underwent HIV testing and 938 (88%) were counselled post-test. The overall HIV-seroprevalence rate was 77%. A total of 693 patients were given cotrimoxazole of whom 14 (2%) manifested minor dermatological reactions. The adjusted relative risk of death in the intervention group compared with the control group was 0.81 (P < 0.001). The number needed to treat with VCT and adjunctive cotrimoxazole to prevent one death during anti-TB treatment was 12.5. INTERPRETATION: This study shows that VCT and adjunctive cotrimoxazole is feasible, safe and reduces mortality rates in TB patients under routine programme conditions. |
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| dc.language |
en |
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| dc.rights |
Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer |
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| dc.title |
Voluntary Counselling, HIV Testing and Adjunctive Cotrimoxazole Reduces Mortality in Tuberculosis Patients in Thyolo, Malawi. |
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