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Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan.

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dc.contributor Kenya Medical Research Institute, Wellcome Trust Collaborative Program, Médecins sans Frontières-Holland, South Sudan Section, Nairobi, Kenya.
dc.creator Ochong, E
dc.creator van den Broek, I
dc.creator Keus, K
dc.creator Nzila, A
dc.date 2003-08
dc.date.accessioned 2017-01-31T07:09:40Z
dc.date.available 2017-01-31T07:09:40Z
dc.identifier Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. 2003, 69 (2):184-7 Am. J. Trop. Med. Hyg.
dc.identifier 0002-9637
dc.identifier 13677373
dc.identifier http://hdl.handle.net/10144/18255
dc.identifier http://fieldresearch.msf.org/msf/handle/10144/18255
dc.identifier The American Journal of Tropical Medicine and Hygiene
dc.identifier.uri http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18255
dc.description Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected. Although amodiaquine is more potent than chloroquine, its effectiveness is reduced in areas where chloroquine resistance is high. We report an association of the P. falciparum chloroquine resistance transporter (pfcrt) gene and the P. falciparum multiple drug resistance 1 (pfmdr1) gene, two chloroquine resistance markers, with chloroquine and amodiaquine efficacy in vivo in southern Sudan. The data show that the allele of the pfcrt gene with a lysine to threonine change at codon 76 is strongly associated with both chloroquine and amodiaquine resistance. No such association was observed with the pfmdr1 gene.
dc.language en
dc.publisher Published by: American Society of Tropical Medicine and Hygiene
dc.relation http://www.ajtmh.org
dc.rights Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.org
dc.title Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan.


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