| dc.contributor |
Medecins sans Frontieres-Holland, India Section, R.G. Baruah Road, Guwahati, Assam 781024, India. patricia10334@yahoo.com |
|
| dc.creator |
Campbell, P |
|
| dc.creator |
Baruah, S |
|
| dc.creator |
Narain, K |
|
| dc.creator |
Rogers, C C |
|
| dc.date |
2006-02 |
|
| dc.date.accessioned |
2017-01-31T07:09:42Z |
|
| dc.date.available |
2017-01-31T07:09:42Z |
|
| dc.identifier |
A randomized trial comparing the efficacy of four treatment regimens for uncomplicated falciparum malaria in Assam state, India. 2006, 100 (2):108-18 Trans. R. Soc. Trop. Med. Hyg. |
|
| dc.identifier |
0035-9203 |
|
| dc.identifier |
16289651 |
|
| dc.identifier |
10.1016/j.trstmh.2005.06.016 |
|
| dc.identifier |
http://hdl.handle.net/10144/18252 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/18252 |
|
| dc.identifier |
Transactions of the Royal Society of Tropical Medicine and Hygiene |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/18252 |
|
| dc.description |
A four-arm drug sensitivity study compared chloroquine, sulfadoxine-pyrimethamine (SP), mefloquine and mefloquine-artesunate in Sonitpur and Karbi Anglong districts in Assam state, India. Two criteria were used to ascertain outcome: success of clinical treatment and parasitologic cure. In Sonitpur, at 14 days, there were 36/56 early and late treatment failures plus late parasitologic failures to chloroquine and 16/56 for SP. In Karbi Anglong, combined treatment failure at 14 days was 16/56 to chloroquine and 8/60 to SP. Mefloquine and mefloquine-artesunate demonstrated 93.9% and 93.6% sustained responses respectively at 42 days. High failure rates to both chloroquine and SP preclude the use of these drugs as first-line treatment for uncomplicated falciparum malaria in this region. A mefloquine-artesunate combination presents an effective alternative utilizing the currently recommended higher dose of mefloquine. |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier |
|
| dc.relation |
http://www.sciencedirect.com/science/journal/00359203 |
|
| dc.rights |
Archived on this site with the kind permission of Elsevier Ltd. and the Royal Society of Tropical Medicine and Hygiene, http://www.rstmh.org/transactions.asp |
|
| dc.title |
A randomized trial comparing the efficacy of four treatment regimens for uncomplicated falciparum malaria in Assam state, India. |
|