| dc.contributor |
Epicentre, Paris, France. |
|
| dc.creator |
Grandesso, F |
|
| dc.creator |
Hagerman, A |
|
| dc.creator |
Kamara, S |
|
| dc.creator |
Lam, E |
|
| dc.creator |
Checchi, F |
|
| dc.creator |
Balkan, S |
|
| dc.creator |
Scollo, G |
|
| dc.creator |
Durand, R |
|
| dc.creator |
Guthmann, J P |
|
| dc.date |
2006-07 |
|
| dc.date.accessioned |
2017-01-31T07:09:28Z |
|
| dc.date.available |
2017-01-31T07:09:28Z |
|
| dc.identifier |
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. 2006, 11 (7):1017-21 Trop. Med. Int. Health |
|
| dc.identifier |
1360-2276 |
|
| dc.identifier |
16827702 |
|
| dc.identifier |
10.1111/j.1365-3156.2006.01655.x |
|
| dc.identifier |
http://hdl.handle.net/10144/17675 |
|
| dc.identifier |
http://fieldresearch.msf.org/msf/handle/10144/17675 |
|
| dc.identifier |
Tropical Medicine & International Health |
|
| dc.identifier.uri |
http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17675 |
|
| dc.description |
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy. METHODS: Method and outcome classification of the study complied with WHO guidelines. Children 6-59 months with uncomplicated malaria were followed-up for 28 days. PCR genotyping was used to distinguish recrudescence from reinfection. Reinfections were reclassified as cured. RESULTS: Of 172 children who were referred to the study clinic, 126 satisfied inclusion criteria and were enrolled. No early treatment failures were reported. The day 14, efficacy was 98.2% (95% CI: 93.8-99.8). Of 65 recurrent parasitaemias analysed by PCR, 17 were recrudescences. The PCR-adjusted day 28 efficacy was 84.5% (95% CI: 76.4-90.7). All true failures occurred in the last 8 days of follow-up. Of 110 children who completed the 28-day follow-up, 54 (49.1%) experienced a novel infection. CONCLUSION: The efficacy of this combination was disappointing. The high reinfection rate suggested little prophylactic effect. In Kailahun a more efficacious combination might be necessary in the future. The efficacy of AS + AQ needs to be monitored in Kailahun and in the other regions of Sierra Leone. |
|
| dc.language |
en |
|
| dc.publisher |
Wiley-Blackwell |
|
| dc.relation |
http://www.blackwell-synergy.com/loi/tmi |
|
| dc.rights |
Archived on this site with the kind permission of Wiley-Blackwell |
|
| dc.title |
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. |
|