| dc.contributor | Medecins Sans Frontieres Holland, The Netherlands. | |
| dc.creator | Seaman, J | |
| dc.creator | Boer, C | |
| dc.creator | Wilkinson, R | |
| dc.creator | de Jong, J | |
| dc.creator | de Wilde, E | |
| dc.creator | Sondorp, H | |
| dc.creator | Davidson, R N | |
| dc.date | 1995-07 | |
| dc.date.accessioned | 2017-01-31T07:09:28Z | |
| dc.date.available | 2017-01-31T07:09:28Z | |
| dc.identifier | Liposomal Amphotericin B (AmBisome) in the Treatment of Complicated Kala-Azar Under Field Conditions. 1995, 21 (1):188-93 Clin. Infect. Dis. | |
| dc.identifier | 1058-4838 | |
| dc.identifier | 7578729 | |
| dc.identifier | http://hdl.handle.net/10144/17671 | |
| dc.identifier | http://fieldresearch.msf.org/msf/handle/10144/17671 | |
| dc.identifier | Clinical Infectious Diseases | |
| dc.identifier.uri | http://dspace.mediu.edu.my:8181/xmlui/handle/10144/17671 | |
| dc.description | An open trial of liposomal amphotericin B (AmBisome [L-AmB]; Vestar, San Dimas, CA) for treatment of complicated visceral leishmaniasis was performed in Sudan. Forty-nine patients were treated, and there were six deaths (12% mortality); these were not attributed to therapy. Thirty-seven patients were selected for the trial because of (1) relapse after treatment with a combination of pentavalent antimony (Sbv) and aminosidine, (2) incomplete parasitological response to Sbv and aminosidine, or (3) severe illness. Drug regimen 1 (3 doses of 3-5 mg/kg, on days 0, 3, and 10) cured 8 (50%) of 16 patients; regimen 2 (6 doses of 3-5 mg/kg, on days 0, 3, 6, 8, 10, and 13) cured 14 (88%) of 16. For four of 10 partial responders, "rescue" therapy with L-AmB alone (3 mg/kg daily for 10 days) resulted in cure. Twelve less-unwell patients received regimen 3 (4 doses of 4-5 mg/kg, on days 0, 2, 5, and 7); seven of 11 patients evaluated (64%) were cured. The optimal regimen of L-AmB in these circumstances is administration of 4 mg/kg on days 0, 3, 6, 8, 10, and 13. | |
| dc.language | en | |
| dc.publisher | Published by: Infectious Diseases Society of America | |
| dc.relation | http://www.journals.uchicago.edu/page/cid/brief.html | |
| dc.rights | Archived on this site with permission and copyright by the Infectious Diseases Society of America | |
| dc.title | Liposomal Amphotericin B (AmBisome) in the Treatment of Complicated Kala-Azar Under Field Conditions. |
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||